人类低级星形细胞瘤中与年龄相关的非随机染色体异常。
Age-related nonrandom chromosomal abnormalities in human low-grade astrocytomas.
作者信息
Thiel G, Lozanova T, Vogel S, Kintzel D, Jänisch W, Witkowski R
机构信息
Institut für Medizinische Genetik der Medizinischen Fakultät (Charité) der Humboldt-Universität zu Berlin.
出版信息
Hum Genet. 1993 Jul;91(6):547-50. doi: 10.1007/BF00205078.
We report a cytogenetic investigation of 55 low-grade astrocytomas in 52 patients, 15 children and 37 adults. In addition to numerical aberrations such as trisomy 7 and gonosomal losses, we found structural and/or numerical aberrations of chromosome 1 in eight astrocytomas. There was a striking difference between the rearranged chromosomes in pediatric and adult patients. Whereas the pediatric tumors revealed monosomies 1p with accompanying trisomy 1q, the astrocytomas in adults showed partial or complete monosomies 1q.
我们报告了对52例患者（15名儿童和37名成人）的55例低级别星形细胞瘤进行的细胞遗传学研究。除了如7号染色体三体和性染色体丢失等数目畸变外，我们在8例星形细胞瘤中发现了1号染色体的结构和/或数目畸变。小儿患者和成年患者重排染色体之间存在显著差异。小儿肿瘤表现为1p单体伴随1q三体，而成人星形细胞瘤则显示1q部分或完全单体。
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