Al jarroudi o, Abda n, Brahmi Sa, Afqir S
Service of Medical Oncology, University Hospital Mohammed VI-Oujda, Mohammed Premier University, Morocco. Email:
Asian Pac J Cancer Prev. 2017 Jan 1;18(1):195-200. doi: 10.22034/APJCP.2017.18.1.195.
Introduction: The triple-negative breast cancer (TNBC), defined by the absence of receptors to oestrogen and progesterone and no histochemical expression of human epidermal receptor -2, is associated with a particularly aggressive behavior. The aim of our study was to determine the clinico-pathological, therapeutic and prognostic features associated with this type of breast cancer in Morocco. Methods: A cohort retrospective study, spread over 3 years, was conducted of 116 breast cancer patients, diagnosed between January 2009 and December 2011 at the Regional Center of Oncology. Epidemiological, clinical, histological and therapeutic data were analyzed. Survival curves at 3 years were estimated by Kaplan-Meier analysis with use of the log-rank test. Results: The proportion of triple-negative breast cancer in our series was 13.2%. The average age was 46.5 years and 20,7% had a previous history of familial breast cancer. Some 56,9% of tumors were greater than 3 cm in diameter. infiltrating ductal carcinoma being the histological type in the majority of cases (75.9%). TNBC was most often associated with a high grade, grade III accounting for 50.9%. Vascular invasion was found in 58.6% of cases. Regarding lymph node involvement, 42.2% had positive lymph nodes and 15.5% featured distant metastases. Neoadjuvant chemotherapy was administrated to 20% of patients with a 23.5% complete pathologic response. The rates for overall survival and disease-free-survival at 3 years for localized stages were 70 and 55.6%, respectively. With metastatic lesions, the figures were 27.5% and 10.3% respectively. Conclusion: The TNBC is correlated with a poor prognosis with a high mortality and early relapse requiring identification of new target therapies and markers for prediction of tumoral response to various treatments.
三阴性乳腺癌（TNBC）是指缺乏雌激素和孕激素受体且人表皮受体-2无组织化学表达的乳腺癌，其行为特别具有侵袭性。我们研究的目的是确定摩洛哥这种类型乳腺癌的临床病理、治疗和预后特征。方法：进行了一项为期3年的队列回顾性研究，研究对象为2009年1月至2011年12月在地区肿瘤中心诊断的116例乳腺癌患者。分析了流行病学、临床、组织学和治疗数据。采用Kaplan-Meier分析和对数秩检验估计3年生存率曲线。结果：我们系列研究中三阴性乳腺癌的比例为13.2%。平均年龄为46.5岁，20.7%有家族性乳腺癌病史。约56.9%的肿瘤直径大于3 cm。大多数病例（75.9%）的组织学类型为浸润性导管癌。TNBC最常与高级别相关，III级占50.9%。58.6%的病例发现有血管侵犯。关于淋巴结受累情况，42.2%有阳性淋巴结，15.5%有远处转移。20%的患者接受了新辅助化疗，完全病理缓解率为23.5%。局限性阶段3年的总生存率和无病生存率分别为70%和55.6%。对于转移性病变，这两个数字分别为27.5%和10.3%。结论：TNBC与预后不良相关，死亡率高且早期复发，需要确定新的靶向治疗方法和预测肿瘤对各种治疗反应的标志物。
