Ahn Sung Gwe, Kim Seung Jun, Kim Cheungyeul, Jeong Joon
Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Department of Biotechnology, BioCore, Seoul, Korea.
J Breast Cancer. 2016 Sep;19(3):223-230. doi: 10.4048/jbc.2016.19.3.223. Epub 2016 Sep 23.
Tumor heterogeneity of triple-negative breast cancer (TNBC) has been the main barrier in conquering breast cancer. To dissect the molecular diversity of TNBC and discover therapeutic targets for TNBC, the molecular classification of TNBC is a prioritized issue in research area. Accordingly, recent studies have been successful in classifying TNBC into several distinct subtypes with specific biologic pathways. Despite the different methodologies used and varied number of final subtypes, these studies identically suggested that TNBC consists of four major subtypes: basal-like, mesenchymal, luminal androgen receptor, and immune-enriched. By reviewing these methods of classifications of TNBC, we highlight the unmet need to develop a molecular classifier suited for TNBC.
三阴性乳腺癌（TNBC）的肿瘤异质性一直是攻克乳腺癌的主要障碍。为剖析TNBC的分子多样性并发现TNBC的治疗靶点，TNBC的分子分类是研究领域的一个优先问题。因此，最近的研究已成功将TNBC分为具有特定生物学途径的几种不同亚型。尽管使用的方法不同且最终亚型数量各异，但这些研究一致表明TNBC由四种主要亚型组成：基底样型、间质型、腔面雄激素受体型和免疫富集型。通过回顾这些TNBC的分类方法，我们强调了开发适用于TNBC的分子分类器的未满足需求。
