前列腺癌患者皮肤纤维瘤摄取 68Ga-PSMA。

68Ga-PSMA Uptake by Dermatofibroma in a Patient With Prostate Cancer.

机构信息

From the Departments of *Nuclear Medicine, †Plastic, Reconstructive and Aesthetic Surgery, ‡Pathology, and §Medical Oncology, Akdeniz University, Antalya; and ∥Department of Nuclear Medicine, Emsey Hospital, Istanbul, Turkey.

出版信息

Clin Nucl Med. 2017 May;42(5):358-360. doi: 10.1097/RLU.0000000000001591.

DOI:10.1097/RLU.0000000000001591

PMID:28240656

Abstract

Prostate-specific membrane antigen (PSMA) is a typ. 2 transmembrane protein that is highly expressed in prostate cancer cells. Ga-PSMA PET/CT imaging is a modality used to determine the extent of prostate cancer. Various other neoplasias may also express PSMA, which appears as Ga-PSMA uptake in PET/CT imaging. A 71-year-old man with prostate cancer underwent Ga-PSMA PET/CT imaging for restaging after having an elevated prostate-specific antigen level. Subcutaneous lesions showing focal PSMA uptake were detected, one of which was excised. The histopathologic diagnosis was dermatofibroma.

摘要

前列腺特异性膜抗原（PSMA）是一种典型的 2 型跨膜蛋白，在前列腺癌细胞中高度表达。Ga-PSMA PET/CT 成像是一种用于确定前列腺癌程度的方法。其他各种肿瘤也可能表达 PSMA，这在 PET/CT 成像中表现为 Ga-PSMA 摄取。一位 71 岁的前列腺癌男性患者因前列腺特异性抗原水平升高而进行 Ga-PSMA PET/CT 成像进行重新分期。检测到皮下病变显示局灶性 PSMA 摄取，其中一个病变被切除。组织病理学诊断为皮肤纤维瘤。