Durhan Gamze, Öztekin Pelin Seher, Ünverdi Hatice, Değirmenci Tülin, Durhan Abdullah, Karakaya Jale, Nercis Koşar Pınar, Necip Köseoğlu Enver, Hücümenoğlu Sema
Department of Radiology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
Department of Pathology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
J Ultrasound Med. 2017 Jun;36(6):1101-1108. doi: 10.7863/ultra.16.06064. Epub 2017 Feb 27.
The aim of this study was to evaluate any association between histological grade, molecular subtypes of breast cancer, and strain elastography, and to investigate whether microcalcification affects the stiffness of tumor in breast cancers with the same histological grade.
Between April 2015 and March 2016, 94 lesions of 94 patients with the diagnosis of invasive ductal carcinoma were included in the study. Strain elastography was performed on all patients before biopsy. Histological grades (Grades 1, 2, and 3), molecular subtypes (luminal A, luminal B, Her-2, and basal-like), and strain ratio (SR) were compared. In the same histological grades, patients were divided into two groups according to the presence of microcalcifications, and the groups were compared with each other.
Compared with Grades 1 (20.5) and 2 (23.7), Grade 3 (11.7) showed lower SR values (Grade 3-2, P = .01; Grade 3-1, P = .2). The groups with microcalcification had slightly higher SR in all histological grades, but not of statistical significance. In molecular subtypes, luminal A and B demonstrated higher SR, whereas HER2 and basal-like had lower SR (P > .05 for all group comparisons).
Grade 3 invasive ductal carcinomas are different from other grades with lower SR values. The presence of microcalcifications and molecular subtypes do not affect elasticity like a high histological grade does.
本研究旨在评估乳腺癌的组织学分级、分子亚型与应变弹性成像之间的关联，并研究微钙化是否会影响相同组织学分级的乳腺癌肿瘤硬度。
2015年4月至2016年3月期间，本研究纳入了94例诊断为浸润性导管癌患者的94个病灶。所有患者在活检前均进行了应变弹性成像检查。比较了组织学分级（1级、2级和3级）、分子亚型（腔面A型、腔面B型、人表皮生长因子受体2型和基底样型）和应变率（SR）。在相同组织学分级中，根据微钙化的存在将患者分为两组，并对两组进行比较。
与1级（20.5）和2级（23.7）相比，3级（11.7）的SR值较低（3级与2级比较，P = 0.01；3级与1级比较，P = 0.2）。在所有组织学分级中，有微钙化的组SR略高，但无统计学意义。在分子亚型中，腔面A型和B型显示出较高的SR，而人表皮生长因子受体2型和基底样型的SR较低（所有组间比较P > 0.05）。
3级浸润性导管癌与其他分级不同，其SR值较低。微钙化的存在和分子亚型不像高组织学分级那样影响弹性。
