3,7-二硝基荧蒽和3,9-二硝基荧蒽诱导大鼠皮下肿瘤

Induction of subcutaneous tumors in rats by 3,7- and 3,9-dinitrofluoranthene.

作者信息

Tokiwa H, Otofuji T, Horikawa K, Sera N, Nakagawa R, Maeda T, Sano N, Izumi K, Otsuka H

机构信息

Department of Health Science, Fukuoka Environmental Research Center, Japan.

出版信息

Carcinogenesis. 1987 Dec;8(12):1919-22. doi: 10.1093/carcin/8.12.1919.

DOI:10.1093/carcin/8.12.1919

PMID:2824085

Abstract

Two dinitrofluoranthenes (DNFs) derived from 3-nitrofluoranthene were purified to over 99%, and tested for tumorigenicity in F344/DuCrj male rats. Rats were inoculated s.c. with 0.05 mg 3,7- or 3,9-DNF twice a week for 10 weeks. All 21 rats given 3,7-DNF and 10 of 11 rats (91%) given 3,9-DNF developed tumors at the injection site by 48 weeks after the first injection. Twenty of the 21 tumors induced by 3,7-DNF and seven of the 10 tumors induced by 3,9-DNF were classified as malignant fibrous histiocytoma, but one tumor in the 3,7-DNF-treated group and three tumors induced by 3,9-DNF showed typical features of rhabdomyosarcoma. The first tumors in 3,9-DNF-treated rats appeared on day 88 (on day average 117), 10 weeks earlier than in 3,7-DNF-treated ones (on day average 186).

摘要

从3-硝基荧蒽衍生得到的两种二硝基荧蒽（DNFs）的纯度被提纯至99%以上，并在F344/DuCrj雄性大鼠中进行了致瘤性测试。大鼠每周皮下接种0.05mg 3,7-或3,9-DNF，共接种10周。在首次注射后48周时，所有21只接种3,7-DNF的大鼠以及11只接种3,9-DNF的大鼠中的10只（91%）在注射部位出现了肿瘤。由3,7-DNF诱导的21个肿瘤中有20个以及由3,9-DNF诱导的10个肿瘤中有7个被归类为恶性纤维组织细胞瘤，但在3,7-DNF处理组中的1个肿瘤以及由3,9-DNF诱导的3个肿瘤表现出横纹肌肉瘤的典型特征。3,9-DNF处理的大鼠中最早的肿瘤出现在第88天（平均117天），比3,7-DNF处理的大鼠（平均186天）早10周。