Shu L L, Yang X Z, Zheng S J
Jiangxi Medical College, Nanchang.
Zhonghua Zhong Liu Za Zhi. 1987 Jul;9(4):276-8.
Human papillomavirus (HPV) infection in the cervix was studied by pathomorphology for the first time in China according to Meisels and Fortin's criteria. Cervical condyloma was found in 257 out of 357 (71.99%) cervical tissues. 141 were simple condyloma, 50 dysplasia with condyloma and 66 carcinoma with condyloma. A zone of continuous transformation was observed between the condyloma and dysplasia or carcinoma. 141 simple condylomas were initially diagnosed as chronic cervicitis in 94 (66.67%) and as dysplasia in 29 (20.57%). The pathomorphologic features of condyloma have not been fully recognized before. In carcinogenesis of the cervical carcinoma, the fact that condyloma associated becomes severer in extent but less in incidence, conforms well to Meisels' view that condyloma is the precursor of carcinoma in situ. It is suggested that HPV infection is closely related to cervical carcinoma.
根据梅塞尔和福廷的标准，中国首次通过病理形态学对宫颈人乳头瘤病毒（HPV）感染进行了研究。在357份宫颈组织中，发现257份（71.99%）存在宫颈尖锐湿疣。其中单纯性尖锐湿疣141例，伴发育异常的尖锐湿疣50例，伴癌的尖锐湿疣66例。在尖锐湿疣与发育异常或癌之间观察到一个连续转化区。141例单纯性尖锐湿疣中，94例（66.67%）最初被诊断为慢性宫颈炎，29例（20.57%）被诊断为发育异常。尖锐湿疣的病理形态学特征以前尚未得到充分认识。在宫颈癌的致癌过程中，尖锐湿疣相关病变范围加重但发生率降低这一事实，与梅塞尔认为尖锐湿疣是原位癌前体的观点非常吻合。提示HPV感染与宫颈癌密切相关。
