Meisels A, Roy M, Fortier M, Morin C, Casas-Cordero M, Shah K V, Turgeon H
Acta Cytol. 1981 Jan-Feb;25(1):7-16.
We report on 162 cases of human papillomavirus (HPV) infection of the cervix seen in a two-year period in which the cell sample showed such marked atypia that errors of interpretation could easily have been made. These atypical condylomata are difficult to diagnose cytologically as well as histologically because they mimic dysplasia or carcinoma in situ and, on smears, even invasive squamous carcinoma. HPV particles associated with fibrillar material were found within nuclei of these lesions; their nature was further proved by the immunoperoxidase test. This new form of HPV infection of the cervix showed a 9.1% rate of progression to more advanced cervical lesions. The cytologic finding of atypical condylomata is an indication for colposcopy, confirmative biopsy and appropriate treatment.
我们报告了在两年期间所见的162例宫颈人乳头瘤病毒（HPV）感染病例，这些病例的细胞样本显示出明显的异型性，很容易造成诊断错误。这些非典型湿疣在细胞学和组织学上都难以诊断，因为它们可模仿发育异常或原位癌，在涂片上甚至可模仿浸润性鳞状细胞癌。在这些病变的细胞核内发现了与纤维状物质相关的HPV颗粒；免疫过氧化物酶试验进一步证实了它们的性质。这种宫颈HPV感染的新形式显示进展为更高级别宫颈病变的发生率为9.1%。非典型湿疣的细胞学发现提示应进行阴道镜检查、确诊性活检及适当治疗。
