Mpanya Godéfroid, Tshefu Antoinette, Likwela Joris Losimba
Association de Santé Familial, 4630 Avenue de la Science, Immeuble USTC, Bloc C, Gombe, Kinshasa, Democratic Republic of Congo.
Ecole de Santé Public de Kinshasa, Kinshasa, Democratic Republic of Congo.
Malar J. 2017 Feb 28;16(1):94. doi: 10.1186/s12936-016-1659-x.
The Democratic Republic of Congo (DRC) is one of the two most leading contributors to the global burden of disease due to malaria. This paper describes the malaria testing and treatment market in the nation's capital province of Kinshasa, including availability of malaria testing and treatment and relative anti-malarial market share for the public and private sector.
A malaria medicine outlet survey was conducted in Kinshasa province in 2013. Stratified multi-staged sampling was used to select areas for the survey. Within sampled areas, all outlets with the potential to sell or distribute anti-malarials in the public and private sector were screened for eligibility. Among outlets with anti-malarials or malaria rapid diagnostic tests (RDT) in stock, a full audit of all available products was conducted. Information collected included product information (e.g. active ingredients, brand name), amount reportedly distributed to patients in the past week, and retail price.
In total, 3364 outlets were screened for inclusion across Kinshasa and 1118 outlets were eligible for the study. Among all screened outlets in the private sector only about one in ten (12.1%) were stocking quality-assured Artemisinin-based Combination Therapy (ACT) medicines. Among all screened public sector facilities, 24.5% had both confirmatory testing and quality-assured ACT available, and 20.2% had sulfadoxine-pyrimethamine (SP) available for intermittent preventive therapy during pregnancy (IPTp). The private sector distributed the majority of anti-malarials in Kinshasa (96.7%), typically through drug stores (89.1% of the total anti-malarial market). Non-artemisinin therapies were the most commonly distributed anti-malarial (50.1% of the total market), followed by non quality-assured ACT medicines (38.5%). The median price of an adult quality-assured ACT was $6.59, and more expensive than non quality-assured ACT ($3.71) and SP ($0.44). Confirmatory testing was largely not available in the private sector (1.1%).
While the vast majority of anti-malarial medicines distributed to patients in Kinshasa province are sold within the private sector, availability of malaria testing and appropriate treatment for malaria is alarmingly low. There is a critical need to improve access to confirmatory testing and quality-assured ACT in the private sector. Widespread availability and distribution of non quality-assured ACT and non-artemisinin therapies must be addressed to ensure effective malaria case management.
刚果民主共和国(DRC)是疟疾造成全球疾病负担的两大主要贡献国之一。本文描述了该国首都金沙萨省的疟疾检测与治疗市场,包括疟疾检测与治疗的可及性以及公共和私营部门抗疟药的相对市场份额。
2013年在金沙萨省开展了一项疟疾药品销售点调查。采用分层多阶段抽样法选择调查区域。在抽样区域内,对公共和私营部门所有有销售或分发抗疟药潜力的销售点进行资格筛选。在有抗疟药或疟疾快速诊断检测(RDT)库存的销售点中,对所有可用产品进行全面审计。收集的信息包括产品信息(如活性成分、品牌名称)、据报道过去一周分发给患者的数量以及零售价格。
金沙萨全省共有3364个销售点接受筛选以纳入研究,其中1118个销售点符合研究要求。在私营部门所有接受筛选的销售点中,只有约十分之一(12.1%)有质量保证的青蒿素类复方疗法(ACT)药物库存。在所有接受筛选的公共部门设施中,24.5%既有确诊检测又有质量保证的ACT,20.2%有周效磺胺 - 乙胺嘧啶(SP)用于孕期间歇性预防治疗(IPTp)。私营部门在金沙萨分发了大部分抗疟药(96.7%),通常通过药店(占抗疟药总市场的89.1%)。非青蒿素疗法是最常分发的抗疟药(占总市场的50.1%),其次是无质量保证的ACT药物(38.5%)。成人质量保证的ACT的中位数价格为6.59美元,比无质量保证的ACT(3.71美元)和SP(0.44美元)更贵。私营部门基本没有确诊检测服务(1.1%)。
虽然在金沙萨省分发给患者的绝大多数抗疟药是在私营部门销售,但疟疾检测和适当的疟疾治疗的可及性低得惊人。迫切需要改善私营部门确诊检测和质量保证的ACT的可及性。必须解决无质量保证的ACT和非青蒿素疗法广泛可得和分发的问题,以确保有效的疟疾病例管理。