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精神分裂症患者及其未患病亲属的局部连接异常：静息态功能磁共振成像研究的荟萃分析

Abnormalities of localized connectivity in schizophrenia patients and their unaffected relatives: a meta-analysis of resting-state functional magnetic resonance imaging studies.

作者信息

Xiao Bo, Wang Shuai, Liu Jianbo, Meng Tiantian, He Yuqiong, Luo Xuerong

机构信息

Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center on Mental Health Disorders, National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2017 Feb 14;13:467-475. doi: 10.2147/NDT.S126678. eCollection 2017.

DOI:10.2147/NDT.S126678
PMID:28243099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5317331/
Abstract

OBJECTIVE

The localized dysfunction of specialized brain regions in schizophrenia patients and their unaffected relatives has been identified in a large-scale brain network; however, evidence is inconsistent. We aimed to identify abnormalities in the localized connectivity in schizophrenia patients and their relatives by conducting a meta-analysis of regional homogeneity (ReHo) studies.

METHODS

Fourteen studies on resting-state functional magnetic resonance imaging, with 316 schizophrenia patients, 342 healthy controls, and 66 unaffected relatives, were included in the meta-analysis. This analysis was performed using anisotropic effect-size-based signed differential mapping software.

RESULTS

Schizophrenia patients showed increased ReHo in right superior frontal gyrus and right superior temporal gyrus, as well as decreased ReHo in left fusiform gyrus, left superior temporal gyrus, left postcentral gyrus, and right precentral gyrus. Unaffected relatives showed decreased ReHo in right insula and right superior temporal gyrus. These results remained widely unchanged in both sensitivity and subgroup analyses.

CONCLUSION

Schizophrenia patients and their unaffected relatives had extensive abnormal localized connectivity in cerebrum, especially in superior temporal gyrus, which were the potential diagnostic markers and expounded the pathophysiological hypothesis for the disorder.

摘要

目的

在大规模脑网络中已发现精神分裂症患者及其未患病亲属存在特定脑区的局部功能障碍；然而，证据并不一致。我们旨在通过对局部一致性（ReHo）研究进行荟萃分析，确定精神分裂症患者及其亲属局部连接性的异常情况。

方法

14项关于静息态功能磁共振成像的研究被纳入荟萃分析，其中包括316例精神分裂症患者、342名健康对照者和66名未患病亲属。使用基于各向异性效应大小的符号差异映射软件进行此分析。

结果

精神分裂症患者右侧额上回和右侧颞上回的ReHo增加，而左侧梭状回、左侧颞上回、左侧中央后回和右侧中央前回的ReHo降低。未患病亲属右侧岛叶和右侧颞上回的ReHo降低。这些结果在敏感性分析和亚组分析中均保持广泛不变。

结论

精神分裂症患者及其未患病亲属在大脑中存在广泛的局部连接异常，尤其是在颞上回，这些异常是潜在的诊断标志物，并阐述了该疾病的病理生理假设。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d653/5317331/dfd60e09d614/ndt-13-467Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d653/5317331/52898a179681/ndt-13-467Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d653/5317331/f222c48c132c/ndt-13-467Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d653/5317331/dfd60e09d614/ndt-13-467Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d653/5317331/52898a179681/ndt-13-467Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d653/5317331/f222c48c132c/ndt-13-467Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d653/5317331/dfd60e09d614/ndt-13-467Fig3.jpg

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