Ruiz-Torras Silvia, Gudayol-Ferré Esteve, Fernández-Vazquez Oscar, Cañete-Massé Cristina, Peró-Cebollero Maribel, Guàrdia-Olmos Joan
Clínica Psicològica de la Universitat de Barcelona, Fundació Josep Finestres, Universitat de Barcelona, Spain.
Universidad Michoacana San Nicolás de Hidalgo, Mexico.
Int J Clin Health Psychol. 2023 Oct-Dec;23(4):100395. doi: 10.1016/j.ijchp.2023.100395. Epub 2023 Jul 21.
In recent years several meta-analyses regarding resting-state functional connectivity in patients with schizophrenia have been published. The authors have used different data analysis techniques: regional homogeneity, seed-based data analysis, independent component analysis, and amplitude of low frequencies. Hence, we aim to perform a meta-analysis to identify connectivity networks with different activation patterns between people diagnosed with schizophrenia and healthy controls using voxel-wise analysis.
We collected primary studies exploring whole brain connectivity by functional magnetic resonance imaging at rest in patients with schizophrenia compared with healthy controls. We identified 25 studies included high-quality studies that included 1285 patients with schizophrenia and 1279 healthy controls.
The results indicate hypoactivation in the right precentral gyrus and the left superior temporal gyrus of patients with schizophrenia compared with healthy controls.
These regions have been linked with some clinical symptoms usually present in Plea with schizophrenia, such as auditory verbal hallucinations, formal thought disorder, and the comprehension and production of gestures.
近年来，已经发表了几项关于精神分裂症患者静息态功能连接性的荟萃分析。作者使用了不同的数据分析技术：局部一致性、基于种子点的数据分析、独立成分分析和低频振幅。因此，我们旨在进行一项荟萃分析，以使用体素级分析确定精神分裂症患者与健康对照者之间具有不同激活模式的连接网络。
我们收集了通过功能磁共振成像探索精神分裂症患者与健康对照者静息时全脑连接性的原始研究。我们确定了25项研究，其中包括高质量研究，这些研究包括1285例精神分裂症患者和1279例健康对照者。
结果表明，与健康对照者相比，精神分裂症患者右侧中央前回和左侧颞上回存在激活不足。
这些区域与精神分裂症患者通常出现的一些临床症状有关，如幻听、形式思维障碍以及手势的理解和产生。
