Ambros R A, Lee E Y, Sharer L R, Khan M Y, Robboy S J
Department of Pathology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103.
Hum Pathol. 1987 Nov;18(11):1109-14. doi: 10.1016/s0046-8177(87)80377-5.
Clinical and necropsy findings in 13 intravenous drug abusers who died of the acquired immunodeficiency syndrome (AIDS) were reviewed and compared with findings in eight patients who acquired the infection through sexual exposure, the most common mode of transmission in AIDS. No differences were found in lymphocyte counts or duration of survival, despite reports that the degree of immunosuppression in intravenous drug abusers with AIDS differs from that in homosexuals. Neoplasms were found in 25 per cent of patients with sexual risks, but not in any drug abusers (0 per cent). Two opportunistic infections (toxoplasmosis and cytomegalovirus pneumonia and esophagitis) were more common in the intravenous drug abuser group. Although cytomegalovirus has been associated with Kaposi's sarcoma, this association was not found in this study. The postmortem findings in both groups were otherwise similar.
对13名死于获得性免疫缺陷综合征（艾滋病）的静脉注射吸毒者的临床和尸检结果进行了回顾，并与8名通过性接触感染艾滋病（艾滋病最常见的传播方式）的患者的结果进行了比较。尽管有报道称，患有艾滋病的静脉注射吸毒者的免疫抑制程度与同性恋者不同，但在淋巴细胞计数或存活时间方面未发现差异。25%有性传播风险的患者发现了肿瘤，但在任何吸毒者中均未发现（0%）。两种机会性感染（弓形虫病、巨细胞病毒性肺炎和食管炎）在静脉注射吸毒者组中更为常见。尽管巨细胞病毒与卡波西肉瘤有关，但在本研究中未发现这种关联。两组的尸检结果在其他方面相似。
