von Giesen H J, Hefter H, Roick H, Mauss S, Arendt G
Department of Neurology, Heinrich Heine University, Düsseldorf, Germany.
J Neurol. 1994 Dec;242(1):20-5. doi: 10.1007/BF00920570.
Motor tests comprising the analysis of postural tremor, most rapid voluntary alternating index finger movements (MRAM) and the rise time of most rapid index finger extensions (CT) allow us to quantify HIV-associated minor motor deficits electrophysiologically. The electrophysiological results in 57 HIV-positive individuals who acquired HIV infection by intravenous drug abuse (IVDA) were compared with those of 57 matched HIV-positive homosexuals and 98 HIV-negative controls to evaluate a possible additional influence of IVDA on motor performance. Motor deficits showed no differences between HIV-positive i.v. drug abusers and homosexuals, revealing a highly significant slowing of MRAM and prolongation of CT to an almost identical extent. Thus, in HIV-infected individuals minor motor deficits are characteristic early signs of subclinical central nervous system involvement regardless of the mode of HIV infection.
运动测试包括对姿势性震颤、最快速的自愿交替食指运动（MRAM）以及最快速食指伸展的上升时间（CT）进行分析，这使我们能够从电生理学角度量化与HIV相关的轻微运动功能缺陷。将57名通过静脉注射药物滥用（IVDA）感染HIV的HIV阳性个体的电生理结果与57名匹配的HIV阳性同性恋者以及98名HIV阴性对照者的结果进行比较，以评估IVDA对运动表现可能产生的额外影响。HIV阳性的静脉注射药物滥用者和同性恋者之间的运动功能缺陷没有差异，显示出MRAM显著减慢以及CT延长到几乎相同的程度。因此，在HIV感染个体中，无论HIV感染方式如何，轻微运动功能缺陷都是亚临床中枢神经系统受累的典型早期迹象。
