通过致瘤性检测在人类肝癌中检测到的转化基因。
Transforming genes in human hepatomas detected by a tumorigenicity assay.
作者信息
Yuasa Y, Sudo K
机构信息
Department of Hygiene, Gunma University School of Medicine.
出版信息
Jpn J Cancer Res. 1987 Oct;78(10):1036-40.
PMID:2824415
Abstract
Two transforming sequences in human hepatomas were detected by means of a tumorigenicity assay in nude mice using transfected NIH3T3 cells. Through hybridization with known oncogene probes, the transforming gene in one hepatoma was found to be the human hst gene. The transforming sequence in the other hepatoma showed no sequence homology with any of the oncogenes examined.
摘要
利用转染的NIH3T3细胞在裸鼠中进行致瘤性试验，检测出了人肝癌中的两个转化序列。通过与已知癌基因探针杂交，发现其中一个肝癌中的转化基因是人hst基因。另一个肝癌中的转化序列与所检测的任何癌基因均无序列同源性。
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