Tsuda T, Nakatani H, Matsumura T, Yoshida K, Tahara E, Nishihira T, Sakamoto H, Yoshida T, Terada M, Sugimura T
Department of Pathology, Hiroshima University School of Medicine.
Jpn J Cancer Res. 1988 May;79(5):584-8. doi: 10.1111/j.1349-7006.1988.tb00026.x.
The hst-1 gene, previously designated as the hst gene, and seven other oncogenes were examined for possible structural changes in esophageal, gastric and colorectal carcinomas by Southern blot hybridization. The hst-1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carcinomas and in all four metastatic tumors of lymph nodes. The degree of amplification ranged from two to eight times. Coamplification of the hst-1 and c-erbB-1 gene was found in one case of esophageal carcinoma. However, no amplification of the hst-1 gene was detected in gastric and colorectal carcinomas.
通过Southern印迹杂交，检测了先前被命名为hst基因的hst - 1基因以及其他七个癌基因在食管癌、胃癌和结直肠癌中是否存在可能的结构变化。在19例食管鳞状细胞癌中的8例（42.1%）以及所有4例淋巴结转移瘤中，hst - 1基因发生了扩增。扩增程度从2倍到8倍不等。在1例食管癌中发现了hst - 1和c - erbB - 1基因的共扩增。然而，在胃癌和结直肠癌中未检测到hst - 1基因的扩增。
