Chavan Santosh S, Supekar Mrudul V, Burate Pralhad A, Rupanwar Bapurao D, Shelke Anil M, Suryavanshi Gurunath
Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, Maharashtra 411008, India.
Org Biomol Chem. 2017 Mar 21;15(11):2385-2391. doi: 10.1039/c7ob00294g. Epub 2017 Feb 28.
A novel Sn(ii)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields. This protocol provides straightforward access to construct the azetidine core through sequential Knoevenagel condensation, hydration and the C-N cyclization reaction.
已实现一种新型的Sn（II）催化的芳香醛与氰基乙酸乙酯的串联环化反应，以良好至优异的产率得到一系列3-取代的氮杂环丁烷-2,4-二酮。该方法通过依次进行Knoevenagel缩合、水合反应和C-N环化反应，提供了一种直接构建氮杂环丁烷核心的方法。
