Yamanashi Hirotomo, Nagaoki Kenji, Kanbara Sinsuke, Shimizu Yuji, Murase Kunihiko, Tsujino Akira, Maeda Takahiro
Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan.
Department of Infectious Diseases, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan.
Oncotarget. 2020 May 12;11(19):1705-1713. doi: 10.18632/oncotarget.27573.
Lower handgrip strength is a manifestation of sarcopenia and frailty, and has been reported to be associated with cerebral microbleeds (CMBs), which appear on T2-weighted magnetic resonance scans as low-intensity spots. However, the underlying mechanism is unknown. We hypothesized that vascular endothelial injury could be the common factor in loss of handgrip strength and CMBs. We aimed to clarify the relationship between handgrip strength and CMBs, with reference to a marker of vascular repair capability.
We conducted a cross-sectional study of 95 60- to 87-year-old Japanese people who underwent brain magnetic resonance imaging in 2016-2017. Baseline information was obtained by trained interviewers regarding the age, sex, smoking status, nutrient intake, cognition, medical history, education, and household income of the participants. Physical activity was assessed using a tri-axial accelerometer. We used the Fried frailty phenotype definition. Multivariable linear regression analysis was performed.
Handgrip strength was independently associated with the presence of CMB after adjustment for age, sex, body mass index, classical cardiovascular risk factors, protein intake, and daily activity (B = -3.43, = 0.027). This association was shown in participants with a low (B = -4.05, = 0.045) but not high platelet count (B=-2.23, = 0.479). Frailty was also independently associated with the presence of CMB after adjustment for confounders (B = 0.57, = 0.014). Although this association was not present in participants a high platelet count, there was a positive trend in those with a low platelet count (B = 0.50, = 0.135).
Platelet count, a marker of vascular repair capability, appears to modify the relationship between handgrip strength and CMBs.
较低的握力是肌肉减少症和虚弱的一种表现，据报道与脑微出血（CMB）有关，脑微出血在T2加权磁共振扫描上表现为低强度斑点。然而，其潜在机制尚不清楚。我们假设血管内皮损伤可能是握力丧失和脑微出血的共同因素。我们旨在参考血管修复能力的标志物，阐明握力与脑微出血之间的关系。
我们对95名年龄在60至87岁之间、于2016 - 2017年接受脑部磁共振成像检查的日本人进行了一项横断面研究。经过培训的访谈者获取了参与者的年龄、性别、吸烟状况、营养摄入、认知、病史、教育程度和家庭收入等基线信息。使用三轴加速度计评估身体活动情况。我们采用了弗里德虚弱表型定义。进行了多变量线性回归分析。
在调整年龄、性别、体重指数、经典心血管危险因素、蛋白质摄入量和日常活动后，握力与脑微出血的存在独立相关（B = -3.43，P = 0.027）。这种关联在血小板计数低的参与者中表现明显（B = -4.05，P = 0.045），而在血小板计数高的参与者中未表现出关联（B = -2.23，P = 0.479）。在调整混杂因素后，虚弱也与脑微出血的存在独立相关（B = 0.57，P = 0.014）。虽然这种关联在血小板计数高的参与者中不存在，但在血小板计数低的参与者中有正向趋势（B = 0.50，P = 0.135）。
血小板计数作为血管修复能力的标志物，似乎改变了握力与脑微出血之间的关系。
