Vischer T L
J Rheumatol Suppl. 1978;4:49-53.
Treatment with levamisole in patients with rheumatoid arthritis reduced significantly titers of rheumatoid factor and the amount of circulating immune complexes as determined by the Clq binding activity. It took between three and six months to observe a significant effect. Levamisole treatment had less effect on the amount of immunoglobulins in serum: the values were rarely abnormal before treatment and the changes were small, but reached statistical significance at six months. The effect on complement and complement components could not be evaluated as properly controlled studies were lacking.
类风湿关节炎患者使用左旋咪唑治疗后，类风湿因子滴度及通过Clq结合活性测定的循环免疫复合物量显著降低。观察到显著效果需要三到六个月的时间。左旋咪唑治疗对血清免疫球蛋白量的影响较小：治疗前这些值很少异常，变化也很小，但在六个月时达到统计学显著性。由于缺乏适当的对照研究，无法评估其对补体及补体成分的影响。
