Westedt M L, Daha M R, de Vries E, Valentijn R M, Cats A
J Rheumatol. 1985 Jun;12(3):449-55.
Serum and synovial fluid (SF) from 68 patients with rheumatoid arthritis (RA) were studied for the presence of immune complexes (IC) and the results correlated with extraarticular features and/or disease activity. IC were measured by the 125I Clq binding assay (ClqBA) and with one detecting IgG, IgA, C3 or C4 in IC. Disease activity correlated significantly with IgG or IgA containing and Clq binding IC. The IgA containing IC were found only in 25% of the patients, including all but one case of rheumatoid vasculitis, but otherwise only in seropositive active RA. C3 and C4 IC did not correlated with disease activity, seropositivity or vasculitis. IC in serum did not correlate with SF levels, but C4 containing IC were more frequent in SF (60%) than in serum (30%). Thus serum IC did not reflect SF levels. Patients with vasculitis showed more IC in the sera than in SF.
对68例类风湿性关节炎（RA）患者的血清和滑液（SF）进行了免疫复合物（IC）检测，并将结果与关节外表现和/或疾病活动度相关联。通过¹²⁵I Clq结合试验（ClqBA）以及一种检测IC中IgG、IgA、C3或C4的方法来测量IC。疾病活动度与含IgG或IgA且能与Clq结合的IC显著相关。仅25%的患者发现含IgA的IC，其中包括除1例类风湿性血管炎外的所有病例，除此之外仅在血清阳性的活动性RA患者中发现。C3和C4 IC与疾病活动度、血清阳性或血管炎无关。血清中的IC与SF水平无关，但含C4的IC在SF中（60%）比在血清中（30%）更常见。因此血清IC不能反映SF水平。血管炎患者血清中的IC比SF中的更多。
