Nicolau Joana, Simó Rafael, Sanchís Pilar, Ayala Luisa, Fortuny Regina, Rivera Rosmeri, Masmiquel Lluís
Endocrinology and Nutrition Department. Hospital Son Llàtzer. Palma de Mallorca, Spain. University Institute of Health Sciences Research (IUNICS) and Health Research Institute of Palma (IdISPa). Palma de Mallorca.
Nutr Hosp. 2017 Feb 1;34(1):81-87. doi: 10.20960/nh.979.
Obesity is linked to a low-grade chronic systemic inflammation that improves after weight loss. Depressive disorder has been suggested to be associated with systemic inflammation up regulation.
We aimed to explore whether, after a significant weight loss, the presence of depressive symptoms was associated with differences in terms of inflammatory markers and quality of life.
Sixty patients (78.3%♀, age 46.4 ± 9.9) who underwent bariatric surgery, with a minimum follow up of 18 months, were evaluated. For the screening of depression, the Beck Depression Inventory (BDI) was administered.
Ten subjects (16.6%) had a positive screening for depressive disorder. The percentage of patients with weight regain was greater among subjects with symptoms of depression (70% vs. 32%; p = 0.024), although no differences were seen regarding BMI prior to surgery and current BMI. Acute phase reactants were higher among subjects with symptoms of depression: platelets (319 ± 15 x 10^12/L vs. 232 ± 47 x 10 ^ 12/L; p = 0.001), erythrocyte sedimentation rate (24.7 ± 11.3 mm vs.17 ± 10 mm; p = 0.03), fibrinogen (486 ± 107 mg/dL vs. 406 ± 66 mg/dL; p = 0.003), ferritin (106 ± 180 ng/ml vs. 34 ± 44 ng/ml; p = 0.014) and ultrasensitive C-reactive protein (0.96 ± 1.84 mg/dL vs. 0.24 ± 0.26 mg/dL; p = 0.008). All domains of quality of life were significantly lower in the depressive group.
Despite a significant weight loss, inflammatory markers are greater and quality of life lower when associated with depressive symptoms.
肥胖与一种低度慢性全身炎症相关，体重减轻后炎症会改善。有研究表明抑郁症与全身炎症上调有关。
我们旨在探讨在显著减重后，抑郁症状的存在是否与炎症标志物和生活质量方面的差异相关。
对60例接受减肥手术的患者（女性占78.3%，年龄46.4±9.9岁）进行评估，最短随访时间为18个月。采用贝克抑郁量表（BDI）进行抑郁筛查。
10名受试者（16.6%）抑郁障碍筛查呈阳性。抑郁症状患者体重反弹的百分比更高（70%对32%；p=0.024），尽管手术前BMI和当前BMI无差异。抑郁症状患者的急性期反应物更高：血小板（319±15×10^12/L对232±47×10^12/L；p=0.001）、红细胞沉降率（24.7±11.3mm对17±10mm；p=0.03）、纤维蛋白原（486±107mg/dL对406±66mg/dL；p=0.003）、铁蛋白（106±180ng/ml对34±44ng/ml；p=0.014）和超敏C反应蛋白（0.96±1.84mg/dL对0.24±0.26mg/dL；p=0.008）。抑郁组生活质量的所有领域均显著较低。
尽管体重显著减轻，但与抑郁症状相关时，炎症标志物更高，生活质量更低。
