Alyahya Rayyan A, Alnujaidi Muhaid A
Pediatrics and Neonatology, Prince Sultan Military Medical City, Riyadh, SAU.
General Surgery, Prince Mohammed Bin Abdulaziz Hospital, Riyadh, SAU.
Cureus. 2022 Jun 4;14(6):e25651. doi: 10.7759/cureus.25651. eCollection 2022 Jun.
Surgeons often focus on weight loss and improvement of obesity-related conditions as a primary outcome after bariatric surgery. However, the success of bariatric surgery also relies on the improvement of mental health status. Therefore, the current meta-analysis was carried out to reveal the prevalence of depressive symptoms and their subsequent impact on bariatric surgery outcomes. This study was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and the recommendation of Cochrane Collaboration. All clinical studies reporting the prevalence and/or the outcomes of depression after bariatric surgery were included in the current meta-analysis. This meta-analysis encompassed 33 articles, including a total of 101,223 patients. The prevalence of post-bariatric surgery depression was 15.3% (95% confidence intervals {CI}: 15.0-15.5%, p<0.001) among which severe, moderate, and minimal depression accounted for 1.9% (95% CI: 1.5-2.4%, p<0.001), 5.1% (95% CI: 4.4-5.8%, p<0.001), and 64.9% (95% CI: 63.3-66.5%, p<0.001), respectively. Depression is negatively correlated with weight loss (correlation -0.135; 95% CI: -0.176 to 0.093; p<0.001) and positively correlated with eating disorder (correlation 0.164; 95% CI: 0.079-0.248; p<0.001). The prevalence of post-bariatric surgery depression is relatively high reaching up to 64.9%, with almost one in five patients affected by it. Depression is associated with weight regain, eating disorders, and quality of life.
外科医生通常将减肥以及改善肥胖相关病症作为减肥手术后的主要疗效指标。然而，减肥手术的成功还依赖于心理健康状况的改善。因此，开展了本次荟萃分析，以揭示抑郁症状的发生率及其对减肥手术疗效的后续影响。本研究是按照系统评价与荟萃分析的首选报告项目（PRISMA）清单以及Cochrane协作网的建议进行的。所有报告减肥手术后抑郁发生率和/或结局的临床研究均纳入了本次荟萃分析。该荟萃分析涵盖33篇文章，共涉及101223例患者。减肥手术后抑郁的发生率为15.3%（95%置信区间{CI}：15.0 - 15.5%，p<0.001），其中重度、中度和轻度抑郁分别占1.9%（95% CI：1.5 - 2.4%，p<0.001）、5.1%（95% CI：4.4 - 5.8%，p<0.001）和64.9%（95% CI：63.3 - 66.5%，p<0.001）。抑郁与体重减轻呈负相关（相关系数 -0.135；95% CI：-0.176至0.093；p<0.001），与饮食失调呈正相关（相关系数0.164；95% CI：0.079 - 0.248；p<0.001）。减肥手术后抑郁的发生率相对较高，高达64.9%，几乎五分之一的患者受其影响。抑郁与体重反弹、饮食失调和生活质量相关。
