用奥昔布宁治疗美沙酮引起的多汗症。
Methadone-Induced Hyperhidrosis Treated With Oxybutynin.
作者信息
Hong Joe, Lee Jooyeon, Totouom-Tangho Holly, Dunn Norma Ramos, Swift Ronnie Gorman
机构信息
Department of Psychiatry, Metropolitan Hospital Center, New York Medical College, New York, NY.
出版信息
J Addict Med. 2017 May/Jun;11(3):237-238. doi: 10.1097/ADM.0000000000000300.
OBJECTIVES
This case report aims to help healthcare providers and methadone clinic patients to recognize one of the less recognized adverse effects of methadone, hyperhidrosis, and to suggest oxybutynin as a possible solution.
METHODS
A 35-year-old man on methadone maintenance therapy presented with excessive sweating, which began promptly after methadone was introduced. Urine toxicology was conducted every 2 weeks to rule out other illicit substances that may have contributed to the sweating.
RESULTS
Oxybutynin (5 mg PO QID) resulted in cessation of the methadone-induced hyperhidrosis within 2 days of starting the medication.
CONCLUSIONS
Methadone-induced excessive sweating is an adverse effect of the medication that reportedly affects up to 45% of those prescribed methadone, and oxybutynin is a potent treatment for methadone-induced excessive sweating.
目的
本病例报告旨在帮助医疗服务提供者和美沙酮诊所患者认识美沙酮较少被认识到的不良反应之一——多汗症，并建议将奥昔布宁作为一种可能的解决方案。
方法
一名接受美沙酮维持治疗的35岁男性出现多汗症状，在开始使用美沙酮后很快就出现了。每2周进行一次尿液毒理学检测，以排除可能导致出汗的其他非法物质。
结果
奥昔布宁（5毫克口服，每日4次）在开始用药后2天内使美沙酮引起的多汗症停止。
结论
美沙酮引起的多汗是该药物的一种不良反应，据报道，高达45%的美沙酮处方患者会受到影响，而奥昔布宁是治疗美沙酮引起的多汗症的有效药物。
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