Jensen Megan E, Gibson Peter G, Collins Clare E, Hilton Jodi M, Wood Lisa G
Priority Research Centre Grow Up Well, School of Biomedical Science & Pharmacy and School of Medicine & Public Health, Faculty of Health & Medicine, University of Newcastle, Newcastle, NSW 2308, Australia.
Priority Research Centre Healthy Lungs, School of Medicine & Public Health, Faculty of Health & Medicine, University of Newcastle, Newcastle, NSW 2308, Australia.
Children (Basel). 2017 Feb 25;4(3):15. doi: 10.3390/children4030015.
A higher proportion of children with asthma are overweight and obese compared to children without asthma; however, it is unknown whether asthmatic children are at increased risk of weight gain due to modifiable lifestyle factors. Thus, the aim of this cross-sectional study was to compare weight-gain risk factors (sleep, appetite, diet, activity) in an opportunistic sample of children with and without asthma. Non-obese children with ( = 17; age 10.7 (2.4) years) and without asthma ( = 17; age 10.8 (2.3) years), referred for overnight polysomnography, underwent measurement of lung function, plasma appetite hormones, dietary intake and food cravings, activity, and daytime sleepiness. Sleep latency (56.6 (25.5) vs. 40.9 (16.9) min, = 0.042) and plasma triglycerides (1.0 (0.8, 1.2) vs. 0.7 (0.7, 0.8) mmol/L, = 0.013) were significantly greater in asthmatic versus non-asthmatic children. No group difference was observed in appetite hormones, dietary intake, or activity levels ( > 0.05). Sleep duration paralleled overall diet quality ( = 0.36, = 0.04), whilst daytime sleepiness paralleled plasma lipids ( = 0.61, =0.001) and sedentary time ( = 0.39, = 0.02). Disturbances in sleep quality and plasma triglycerides were evident in non-obese asthmatic children referred for polysomnography, versus non-asthmatic children. Observed associations between diet quality, sedentary behavior, and metabolic and sleep-related outcomes warrant further investigation, particularly the long-term health implications.
与没有哮喘的儿童相比，患有哮喘的儿童超重和肥胖的比例更高；然而，尚不清楚哮喘儿童是否由于可改变的生活方式因素而增加了体重增加的风险。因此，这项横断面研究的目的是比较有和没有哮喘的儿童机会性样本中的体重增加风险因素（睡眠、食欲、饮食、活动）。因夜间多导睡眠图检查而转诊的非肥胖哮喘儿童（n = 17；年龄10.7（2.4）岁）和非哮喘儿童（n = 17；年龄10.8（2.3）岁）接受了肺功能、血浆食欲激素、饮食摄入量和食物渴望、活动以及日间嗜睡情况的测量。哮喘儿童的睡眠潜伏期（56.6（25.5）对40.9（16.9）分钟，P = 0.042）和血浆甘油三酯水平（1.0（0.8，1.2）对0.7（0.7，0.8）mmol/L，P = 0.013）显著高于非哮喘儿童。在食欲激素、饮食摄入量或活动水平方面未观察到组间差异（P>0.05）。睡眠时间与总体饮食质量平行（r = 0.36，P = 0.04），而日间嗜睡与血浆脂质平行（r = 0.61，P = 0.001）和久坐时间平行（r = 0.39，P = 0.02）。与接受多导睡眠图检查的非哮喘儿童相比，非肥胖哮喘儿童存在睡眠质量和血浆甘油三酯紊乱。观察到的饮食质量、久坐行为与代谢和睡眠相关结果之间的关联值得进一步研究，特别是对长期健康的影响。
