Department of Chemistry, Acadia University, Wolfville, NS B4P 2R6. Canada.
Mini Rev Med Chem. 2017;17(15):1425-1434. doi: 10.2174/1389557517666170228114234.
This is a short review on the most recent studies on curcumin and its analogs, including the studies from the laboratories of authors. The diverse medicinal properties of curcumin itself reported in the recent years are reviewed. Although curcumin has shown great potential in treating various diseases, it has not been approved as a clinical drug candidate because of its poor pharmacokinetics.
The recent methods developed to solve this problem are briefly described.
The biological and other properties of synthetic curcumin analogs (diarylheptanoids and diarylpentanoid monocarbonyl derivatives) reported in the recent literature are also presented.
这是一篇关于姜黄素及其类似物的最新研究的简短综述，包括作者实验室的研究。综述了近年来报道的姜黄素本身具有的多种药用特性。尽管姜黄素在治疗各种疾病方面显示出巨大的潜力，但由于其药代动力学不佳，尚未被批准为临床候选药物。
简要描述了最近为解决这一问题而开发的方法。
还介绍了近期文献中报道的合成姜黄素类似物（二芳基庚烷和二芳基戊烷单羰基衍生物）的生物学和其他特性。
