Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Chhatrapati Sambhajinagar (Aurangabad), Maharashtra, India.
Department of Chemistry, Khopoli Municipal Council College, Khopoli, Maharashtra, India.
Arch Pharm (Weinheim). 2024 Sep;357(9):e2400197. doi: 10.1002/ardp.202400197. Epub 2024 Jun 19.
Monocarbonyl analogs of curcumin (MACs) represent structurally modified versions of curcumin. The existing literature indicates that MACs exhibit enhanced anticancer properties compared with curcumin. Numerous research articles in recent years have emphasized the significance of MACs as effective anticancer agents. This review focuses on the latest advances in the anticancer potential of MACs, from 2014 to 2024, including discussions on their mechanism of action, structure-activity relationship (SAR), and in silico molecular docking studies.
姜黄素的单羰基类似物（MACs）是姜黄素的结构修饰物。现有文献表明，MACs 比姜黄素具有更强的抗癌特性。近年来，许多研究文章强调了 MACs 作为有效抗癌剂的重要性。本综述重点介绍了 2014 年至 2024 年期间 MACs 的抗癌潜力的最新进展，包括其作用机制、构效关系（SAR）和计算机分子对接研究的讨论。
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