Jeffrey Cheah School of Medicine & Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.
Laboratory of Natural Products, Faculty of Science, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia.
Biomolecules. 2019 Jul 10;9(7):270. doi: 10.3390/biom9070270.
While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an attractive avenue for anticancer research owing to the multifactorial nature of cancer itself. The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in particular have shown improved cytotoxicity over curcumin. Investigations of diarylpentanoids have demonstrated that these compounds exert anti-cancer effects through several signalling pathways that are associated with cancer. This review focuses on selected diarylpentanoids and highlights molecular targets that modulate key pathways involved in cancer such as NF-κB, MAPK/ERK, and STAT signalling. Future research will need to focus on drug interactions to explore potential synergistic actions of diarylpentanoids and further establish the use of diverse animal models.
姜黄素具有多种治疗功效，但其强大的抗癌活性仍然是抗癌研究的一个有吸引力的途径，因为癌症本身具有多因素的性质。因此，姜黄素的结构被用作设计更有效的类似物的先导，特别是二芳基戊烷类化合物显示出比姜黄素更高的细胞毒性。对二芳基戊烷类化合物的研究表明，这些化合物通过与癌症相关的几种信号通路发挥抗癌作用。本综述重点介绍了选定的二芳基戊烷类化合物，并强调了调节 NF-κB、MAPK/ERK 和 STAT 信号等关键通路的分子靶点在癌症中的作用。未来的研究需要集中在药物相互作用上，以探索二芳基戊烷类化合物的潜在协同作用，并进一步建立使用不同的动物模型。
