诱导多能干细胞选择性细胞死亡的技术方法。
Technical approaches to induce selective cell death of pluripotent stem cells.
作者信息
Jeong Ho-Chang, Cho Seung-Ju, Lee Mi-Ok, Cha Hyuk-Jin
机构信息
Dept. of Life Sciences, College of Natural Sciences, Sogang University, #1 Sinsu-dong, Mapo-gu, Seoul,, 121-742, Republic of Korea.
Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon,, 305-806, Republic of Korea.
出版信息
Cell Mol Life Sci. 2017 Jul;74(14):2601-2611. doi: 10.1007/s00018-017-2486-0. Epub 2017 Feb 28.
Abstract
Despite the recent promising results of clinical trials using human pluripotent stem cell (hPSC)-based cell therapies for age-related macular degeneration (AMD), the risk of teratoma formation resulting from residual undifferentiated hPSCs remains a serious and critical hurdle for broader clinical implementation. To mitigate the tumorigenic risk of hPSC-based cell therapy, a variety of approaches have been examined to ablate the undifferentiated hPSCs based on the unique molecular properties of hPSCs. In the present review, we offer a brief overview of recent attempts at selective elimination of undifferentiated hPSCs to decrease the risk of teratoma formation in hPSC-based cell therapy.
摘要
尽管最近使用基于人多能干细胞（hPSC）的细胞疗法治疗年龄相关性黄斑变性（AMD）的临床试验取得了令人鼓舞的结果，但残留的未分化hPSC导致畸胎瘤形成的风险仍然是更广泛临床应用的一个严重且关键的障碍。为了降低基于hPSC的细胞疗法的致瘤风险，人们已经研究了多种基于hPSC独特分子特性来消除未分化hPSC的方法。在本综述中，我们简要概述了最近为选择性消除未分化hPSC以降低基于hPSC的细胞疗法中畸胎瘤形成风险所做的尝试。
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