Sönnerstam Eva, Sjölander Maria, Gustafsson Maria
Department of Pharmacology and Clinical Neuroscience, Division of Clinical Pharmacology, Umeå University, SE-901 87, Umeå, Sweden.
Eur J Clin Pharmacol. 2017 Jun;73(6):735-742. doi: 10.1007/s00228-017-2218-2. Epub 2017 Mar 1.
As people get older, their sensitivity to drugs and adverse drug reactions can increase due to pharmacokinetic and pharmacodynamic changes. Older people with dementia are a particularly vulnerable group of people. They are at an increased risk of being prescribed potentially inappropriate medications, which may lead to harmful consequences. The aim of this study was to investigate the prevalence of potentially inappropriate medications among older patients with cognitive impairment.
Medical records for patients aged ≥65 years admitted to two hospitals in Northern Sweden were reviewed. Potentially inappropriate medications were identified using the EU(7)-PIM list as an identification tool.
Of 428 patients included in the study, 40.9% had one or more potentially inappropriate medication prescribed. The most commonly represented potentially inappropriate medication classes were hypnotics and sedatives, cardiovascular drugs and laxatives. The most commonly involved potentially inappropriate medications were zopiclone, digoxin and sodium picosulfate. There was an association seen between having a higher number of medications prescribed and having one or more potentially inappropriate medication.
Potentially inappropriate medications are prevalent among older people with cognitive impairment living in Northern Sweden. It is important to continuously evaluate the need for potentially inappropriate medications in this patient group, in order to prevent adverse drug reactions, especially among those who have a higher number of medications prescribed.
随着年龄增长，由于药代动力学和药效学变化，人们对药物的敏感性及药物不良反应可能会增加。患有痴呆症的老年人是特别脆弱的群体。他们被开具潜在不适当药物的风险增加，这可能会导致有害后果。本研究的目的是调查老年认知障碍患者中潜在不适当药物的流行情况。
回顾了瑞典北部两家医院收治的年龄≥65岁患者的病历。使用欧盟（7）-PIM清单作为识别工具来识别潜在不适当药物。
在纳入研究的428名患者中，40.9%的患者被开具了一种或多种潜在不适当药物。最常见的潜在不适当药物类别是催眠药和镇静剂、心血管药物和泻药。最常涉及的潜在不适当药物是佐匹克隆、地高辛和比沙可啶钠。开具的药物数量较多与开具一种或多种潜在不适当药物之间存在关联。
在瑞典北部生活的老年认知障碍患者中，潜在不适当药物很普遍。持续评估该患者群体中潜在不适当药物的必要性很重要，以预防药物不良反应，尤其是在开具药物数量较多的患者中。
