[微小RNA作为泌尿外科恶性肿瘤诊断中潜在的非侵入性标志物]
[MicroRNAs as potential noninvasive markers in the diagnosis of urological malignancies].
作者信息
Gilyazova I R, Klimentova E A, Pavlov V N, Khusnutdinova E K
机构信息
Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences.
Bashkir State Medical University, Department of Urology, Ufa.
出版信息
Urologiia. 2016 Apr(2):96-102.
Small non-coding RNAs (microRNAs) are involved in almost all biological mechanisms of carcinogenesis. Due to their stability in biological fluids microRNAs may serve a perspective biomarker for diagnosis and prognosis of oncological diseases. The review is dedicated to the analysis of microRNAs, as potential diagnostic markers of urological malignancies. Recent advances in the knowledge of miRNAs origin in body fluids, their stability and application as a potentially new class of biomarkers in medicine are summarized and discussed in the article.
小非编码RNA（微小RNA）几乎参与了癌症发生的所有生物学机制。由于其在生物体液中的稳定性，微小RNA可能成为肿瘤疾病诊断和预后的一种有前景的生物标志物。这篇综述致力于分析微小RNA作为泌尿系统恶性肿瘤潜在诊断标志物的情况。文章总结并讨论了关于miRNA在体液中的起源、稳定性及其作为医学中一类潜在新生物标志物的应用的最新知识进展。
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