Bouhenni Rachida, Dunmire Jeffrey, Rowe Theresa, Bates James
Ophthalmology Department, Summa Health System, 525 East Market St, 274 Old Medical Building, Akron, OH 44304, USA.
Proteomes. 2015 Dec 14;3(4):496-511. doi: 10.3390/proteomes3040496.
Bacterial keratitis is a serious ocular infection that can cause severe visual loss if treatment is not initiated at an early stage. It is most commonly caused by or species. Depending on the invading organism, bacterial keratitis can progress rapidly, leading to corneal destruction and potential blindness. Common risk factors for bacterial keratitis include contact lens wear, ocular trauma, ocular surface disease, ocular surgery, lid deformity, chronic use of topical steroids, contaminated ocular medications or solutions, and systemic immunosuppression. The pathogenesis of bacterial keratitis, which depends on the bacterium-host interaction and the virulence of the invading bacterium, is complicated and not completely understood. This review highlights some of the proteomic technologies that have been used to identify virulence factors and the host response to infections of bacterial keratitis in order to understand the disease process and develop improved methods of diagnosis and treatment. Although work in this field is not abundant, proteomic technologies have provided valuable information toward our current knowledge of bacterial keratitis. More studies using global proteomic approaches are warranted because it is an important tool to identify novel targets for intervention and prevention of corneal damage caused by these virulent microorganisms.
细菌性角膜炎是一种严重的眼部感染，如果不及早治疗可导致严重视力丧失。它最常见由 或 菌种引起。根据入侵的微生物不同，细菌性角膜炎可迅速进展，导致角膜破坏并可能致盲。细菌性角膜炎的常见危险因素包括佩戴隐形眼镜、眼外伤、眼表疾病、眼科手术、眼睑畸形、长期使用局部类固醇、受污染的眼用药物或溶液以及全身免疫抑制。细菌性角膜炎的发病机制取决于细菌与宿主的相互作用以及入侵细菌的毒力，较为复杂且尚未完全明确。本综述重点介绍了一些已用于鉴定毒力因子以及宿主对细菌性角膜炎感染反应的蛋白质组学技术，以便了解疾病过程并开发改进的诊断和治疗方法。尽管该领域的研究并不丰富，但蛋白质组学技术已为我们目前对细菌性角膜炎的认识提供了有价值的信息。有必要开展更多使用整体蛋白质组学方法的研究，因为它是识别干预和预防由这些有毒微生物引起的角膜损伤新靶点的重要工具。
