GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore 560 099, India.
Cornea and Refractive Services, Narayana Nethralaya, Bangalore 560 010, India.
Int J Mol Sci. 2022 Mar 14;23(6):3111. doi: 10.3390/ijms23063111.
Infection mediated ocular surface stress responses are activated as early defense mechanisms in response to host cell damage. Integrated stress responses initiate the host response to different types of infections and modulate the transcription of key genes and translation of proteins. The crosstalk between host and pathogen results in profound alterations in cellular and molecular homeostasis triggering specific stress responses in the infected tissues. The amplitude and variations of such responses are partly responsible for the disease severity and clinical sequelae. Understanding the etiology and pathogenesis of ocular infections is important for early diagnosis and effective treatment. This review considers the molecular status of infection mediated ocular surface stress responses which may shed light on the importance of the host stress-signaling pathways. In this review, we collated literature on the molecular studies of all ocular surface infections and summarize the results from such studies systematically. Identification of important mediators involved in the crosstalk between the stress response and activation of diverse signaling molecules in host ocular surface infection may provide novel molecular targets for maintaining the cellular homeostasis during infection. These targets can be then explored and validated for diagnostic and therapeutic purposes.
感染介导的眼表应激反应作为宿主细胞损伤的早期防御机制被激活。综合应激反应启动宿主对不同类型感染的反应，并调节关键基因的转录和蛋白质的翻译。宿主和病原体之间的相互作用导致细胞和分子内稳态的深刻改变，从而在感染组织中引发特定的应激反应。这种反应的幅度和变化部分决定了疾病的严重程度和临床后果。了解眼部感染的病因和发病机制对于早期诊断和有效治疗非常重要。本综述考虑了感染介导的眼表应激反应的分子状态，这可能揭示了宿主应激信号通路的重要性。在本综述中，我们汇集了所有眼表感染的分子研究文献，并系统地总结了这些研究的结果。鉴定参与应激反应与宿主眼表感染中不同信号分子激活之间相互作用的重要介质，可能为维持感染过程中的细胞内稳态提供新的分子靶点。然后可以探索和验证这些靶点用于诊断和治疗目的。
