Llarena Ann-Katrin, Taboada Eduardo, Rossi Mirko
Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
National Microbiology Laboratory at Lethbridge, Animal Diseases Research Institute, Public Health Agency of Canada, Lethbridge, Alberta, Canada.
J Clin Microbiol. 2017 May;55(5):1269-1275. doi: 10.1128/JCM.00017-17. Epub 2017 Mar 1.
This review describes the current state of knowledge regarding the application of whole-genome sequencing (WGS) in the epidemiology of , the leading cause of bacterial gastroenteritis worldwide. We describe how WGS has increased our understanding of the evolutionary and epidemiological dynamics of this pathogen and how WGS has the potential to improve surveillance and outbreak detection. We have identified hurdles to the full implementation of WGS in public health settings. Despite these challenges, we think that ample evidence is available to support the benefits of integrating WGS into the routine monitoring of infections and outbreak investigations.
本综述描述了关于全基因组测序（WGS）在全球细菌性肠胃炎主要病因——[病原体名称未给出]流行病学中的应用的当前知识状态。我们阐述了WGS如何增进我们对该病原体进化和流行病学动态的理解，以及WGS如何有潜力改善监测和疫情检测。我们已经确定了在公共卫生环境中全面实施WGS的障碍。尽管存在这些挑战，但我们认为有充分的证据支持将WGS整合到[病原体名称未给出]感染的常规监测和疫情调查中的益处。
