He Yiping, Kanrar Siddhartha, Reed Sue, Lee Joe, Capobianco Joseph
Characterization and Interventions for Foodborne Pathogens Research Unit, Eastern Regional Research Center, Agricultural Research Service (ARS), United States Department of Agriculture (USDA), 600 East Mermaid Lane, Wyndmoor, PA 19038, USA.
Microorganisms. 2024 Jan 13;12(1):159. doi: 10.3390/microorganisms12010159.
is a leading bacterial cause of gastrointestinal infections in humans and has imposed substantial medical and public health burdens worldwide. Among a total of 39 species in the genus, is the most important species responsible for approx. 90% of human illness. Most cases of the infection were acquired by ingesting undercooked poultry meat due to the high prevalence of in the products. Here, we reported the dataset of raw sequences, de novo assembled and annotated genomes of strains S27, S33, and S36 recently isolated from retail chicken by using PacBio highly accurate long-read sequencing technology combined with bioinformatics tools. Our data revealed several virulence and antibiotic resistance genes in each of the chromosomes, a type IV secretion system in the plasmid (pCjS33) of S33, and a type VI secretion system and a phage in the plasmid (pCjS36) of S36. This study not only provides new sequence data but also extends the knowledge pertaining to the genomic and functional aspects of this important foodborne pathogen, including the genetic determinants of virulence and antibiotic resistance.
是人类胃肠道感染的主要细菌病因，在全球范围内造成了巨大的医疗和公共卫生负担。在该属的总共39个物种中，是导致约90%人类疾病的最重要物种。由于该菌在产品中普遍存在，大多数感染病例是通过摄入未煮熟的禽肉获得的。在此，我们报告了最近使用PacBio高准确度长读长测序技术结合生物信息学工具从零售鸡肉中分离出的菌株S27、S33和S36的原始序列数据集、从头组装和注释的基因组。我们的数据揭示了每个染色体中的几个毒力和抗生素抗性基因、S33质粒（pCjS33）中的IV型分泌系统以及S36质粒（pCjS36）中的VI型分泌系统和一个噬菌体。本研究不仅提供了新的序列数据，还扩展了有关这种重要食源性病原体的基因组和功能方面的知识，包括毒力和抗生素抗性的遗传决定因素。
