Peyron Christelle, Kilduff Thomas S
Center for Research in Neuroscience of Lyon, Sleep team, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5292, Institut National de la Santé et de la Recherche Médicale U1028, Université Claude Bernard Lyon 1, Lyon, France, and
Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California 94025.
J Neurosci. 2017 Mar 1;37(9):2268-2272. doi: 10.1523/JNEUROSCI.1708-16.2016.
Early in 1998, we (de Lecea et al., 1998) and others (Sakurai et al., 1998) described the same hypothalamic neuropeptides, respectively called the hypocretins or orexins, which were discovered using two different approaches. In December of that year, we published the subject of this commentary in the : a highly detailed anatomical description of the extensive axonal projections of the hypocretin/orexin neurons. Although the function of this system was unknown at the time, a large body of literature today attests that the hypocretin/orexin neuropeptides play important roles in multiple physiological functions, particularly in sleep/wake regulation. Neuroanatomical studies are rarely frontline news, but the citation rate of this paper underscores the critical nature of such basic research. Based in part on this detailed description, the hypocretin/orexin neuropeptides have since been studied in many different areas of neuroscience research, including sleep/wake regulation, feeding, addiction, reward and motivation, anxiety and depression, cardiovascular regulation, pain, migraine, and neuroendocrine regulation, including reproduction. Thus, this paper has had a surprisingly broad impact on neuroscience research, particularly since it was originally rejected by the !
1998年初，我们（德·莱西等人，1998年）和其他人（樱井等人，1998年）分别描述了同一种下丘脑神经肽，分别称为下丘脑泌素或食欲素，它们是通过两种不同的方法发现的。同年12月，我们在《》上发表了这篇评论的主题：对下丘脑泌素/食欲素神经元广泛轴突投射的高度详细的解剖学描述。尽管当时这个系统的功能尚不清楚，但如今大量文献证明，下丘脑泌素/食欲素神经肽在多种生理功能中发挥着重要作用，尤其是在睡眠/觉醒调节方面。神经解剖学研究很少成为前沿新闻，但这篇论文的引用率凸显了此类基础研究的重要性。部分基于这一详细描述，此后下丘脑泌素/食欲素神经肽在神经科学研究的许多不同领域得到了研究，包括睡眠/觉醒调节、进食、成瘾、奖赏与动机、焦虑与抑郁、心血管调节、疼痛、偏头痛以及神经内分泌调节，包括生殖。因此，这篇论文对神经科学研究产生了惊人的广泛影响，尤其是因为它最初被《》拒绝了！
