食欲肽、睡眠与血压。
Orexins, Sleep, and Blood Pressure.
机构信息
Department of Emergency Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-235, Gdansk, Poland.
Department of Neurology, University of Helsinki, Helsinki, Finland.
出版信息
Curr Hypertens Rep. 2018 Jul 10;20(9):79. doi: 10.1007/s11906-018-0879-6.
PURPOSE OF REVIEW
The aim of this review was to summarize collected data on the role of orexin and orexin neurons in the control of sleep and blood pressure.
RECENT FINDINGS
Although orexins (hypocretins) have been known for only 20 years, an impressive amount of data is now available regarding their physiological role. Hypothalamic orexin neurons are responsible for the control of food intake and energy expenditure, motivation, circadian rhythm of sleep and wake, memory, cognitive functions, and the cardiovascular system. Multiple studies show that orexinergic stimulation results in increased blood pressure and heart rate and that this effect may be efficiently attenuated by orexinergic antagonism. Increased activity of orexinergic neurons is also observed in animal models of hypertension. Pharmacological intervention in the orexinergic system is now one of the therapeutic possibilities in insomnia. Although the role of orexin in the control of blood pressure is well described, we are still lacking clinical evidence that this is a possibility for a new approach in the treatment of cardiovascular diseases.
目的综述
本文旨在总结收集到的关于食欲素和食欲素神经元在睡眠和血压控制中的作用的数据。
最近的发现
尽管食欲素（下丘脑分泌素）仅被发现了 20 年，但现在已经有大量关于其生理作用的数据。下丘脑食欲素神经元负责控制食物摄入和能量消耗、动机、睡眠和觉醒的昼夜节律、记忆、认知功能和心血管系统。多项研究表明，食欲素能刺激会导致血压和心率升高，而这种效应可以通过食欲素能拮抗作用有效地减弱。在高血压动物模型中也观察到食欲素能神经元活性增加。现在，在食欲素能系统中的药物干预是失眠的治疗可能性之一。尽管食欲素在血压控制中的作用已得到很好的描述，但我们仍然缺乏临床证据表明这是治疗心血管疾病的新方法的可能性。
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