Lunde S, Nesland J M, Holm R, Johannessen J V
Department of Pathology, Norwegian Radium Hospital and Institute for Cancer Research, Oslo.
Pathol Res Pract. 1987 Oct;182(5):627-31.
Protein S-100 immunoreactivity was observed in 5 of 50 breast carcinomas (3 infiltrating lobular and 2 infiltrating ductal carcinomas). A diffuse cytoplasmic staining was present in single cells and groups of cells. The majority of normal myoepithelial cells in ducts of unremarkable appearance next to tumor areas were stained in all 50 breast carcinomas. The 5 protein S-100 positive tumors all stained for prekeratin and 4 of them were vimentin-positive. No immunoreactivity for actin or NSE was observed in the 5 tumors. Electron microscopy did not distinguish the protein S-100 positive carcinomas from the 45 protein S-100 negative tumors. The significance of protein S-100 immunostaining in breast carcinomas is discussed.
在50例乳腺癌中，有5例（3例浸润性小叶癌和2例浸润性导管癌）观察到S-100蛋白免疫反应性。单个细胞和细胞群中存在弥漫性细胞质染色。在所有50例乳腺癌中，肿瘤区域旁外观正常的导管中的大多数正常肌上皮细胞均被染色。5例S-100蛋白阳性肿瘤均对角蛋白染色，其中4例波形蛋白阳性。在这5例肿瘤中未观察到肌动蛋白或神经元特异性烯醇化酶的免疫反应性。电子显微镜无法区分5例S-100蛋白阳性癌与45例S-100蛋白阴性肿瘤。文中讨论了S-100蛋白免疫染色在乳腺癌中的意义。
