Madzima Takudzwa A, Ormsbee Michael J, Schleicher Erica A, Moffatt Robert J, Panton Lynn B
1Department of Exercise Science, Elon University, Elon, NC; 2Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL; 3Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL; 4Discipline of Biokinetics, Exercise and Leisure Studies, University of KwaZulu-Natal, Durban, SOUTH AFRICA; and 5Institute of Successful Longevity, Florida State University, Tallahassee, FL.
Med Sci Sports Exerc. 2017 Jul;49(7):1283-1292. doi: 10.1249/MSS.0000000000001250.
This study aimed to evaluate 12 wk of resistance training (RT; n = 16) and protein supplementation (RT + protein; n = 17) on muscular strength, body composition, and blood biomarkers of muscle (insulin-like growth factor 1 [IGF-1]), fat (adiponectin), and inflammation (human C-reactive protein [CRP]) in breast cancer survivors (BCS).
Thirty-three BCS (59 ± 8 yr) were measured pre- and posttraining for one-repetition maximum (1-RM) muscular strength (chest press and leg extension), body composition (lean mass [LM] and fat mass [FM]) via dual-energy x-ray absorptiometry, and serum concentrations of IGF-1, adiponectin, and CRP. RT consisted of 2 d·wk using 10 exercises for two sets of 10-12 repetitions and a third set to failure at ~65%-85% of 1-RM. RT + protein consumed 20 g of protein twice a day. ANOVA was used for analyses. Significance was set at P ≤ 0.05.
Average RT intensity was 65%-81% of 1-RM and was not different between RT and RT + protein. There were no group-time interactions for strength, LM, FM, and biomarkers. Both groups significantly increased upper (+31 ± 18 kg) and lower (+19 ± 12 kg) body strength, LM (+0.9 ± 1.0 kg) and decreased FM (-0.5 ± 1.2 kg), and percent body fat (-1.0% ± 1.2%). Serum levels of IGF-1 significantly increased from baseline to 12 wk in both RT (102 ± 34 to 115 ± 33 ng·mL) and RT + protein (110 ± 40 to 119 ± 37 ng·mL); adiponectin and CRP did not change.
Twelve weeks of RT at 65%-81% of 1-RM, 2 d·wk in BCS, was well tolerated and significantly improved strength, body composition, and IGF-1. Supplemental protein (40 g·d) did not induce a change in any variable. However, on the basis of food logs, reductions in total calories and dietary protein intake from whole foods resulted in only a net protein increase of 17 g·d for RT + protein, which may have influenced the results.
本研究旨在评估12周的抗阻训练（RT；n = 16）和补充蛋白质（RT + 蛋白质；n = 17）对乳腺癌幸存者（BCS）肌肉力量、身体成分以及肌肉（胰岛素样生长因子1 [IGF-1]）、脂肪（脂联素）和炎症（人C反应蛋白 [CRP]）血液生物标志物的影响。
对33名BCS（59 ± 8岁）在训练前后测量了一次最大重复次数（1-RM）的肌肉力量（卧推和腿伸展）、通过双能X线吸收法测量身体成分（瘦体重 [LM] 和脂肪量 [FM]）以及IGF-1、脂联素和CRP的血清浓度。RT包括每周2天，进行10项练习，每组10 - 12次重复，第三组在1-RM的65% - 85%时进行至力竭。RT + 蛋白质组每天摄入20克蛋白质两次。采用方差分析进行分析。显著性设定为P ≤ 0.05。
RT的平均强度为1-RM的65% - 81%，RT组和RT + 蛋白质组之间无差异。在力量、LM、FM和生物标志物方面，两组与时间之间均无交互作用。两组的上肢（+31 ± 18千克）和下肢（+19 ± 12千克）力量、LM（+0.9 ± 1.0千克）均显著增加，FM（-0.5 ± 1.2千克）和体脂百分比（-1.0% ± 1.2%）均显著降低。RT组（从102 ± 34至115 ± 33纳克·毫升）和RT + 蛋白质组（从110 ± 40至119 ± 37纳克·毫升）血清IGF-1水平从基线至12周均显著升高；脂联素和CRP未发生变化。
BCS进行12周的RT，强度为1-RM的65% - 81%，每周2天，耐受性良好，显著改善了力量、身体成分和IGF-1。补充蛋白质（40克/天）未引起任何变量的变化。然而，根据食物记录，RT +蛋白质组从全食物中摄入的总热量和膳食蛋白质摄入量减少，导致净蛋白质增加仅为17克/天，这可能影响了结果。
