钾通道候选基因可预测乳腺癌手术后继发性淋巴水肿的发生。
Potassium Channel Candidate Genes Predict the Development of Secondary Lymphedema Following Breast Cancer Surgery.
作者信息
Smoot Betty, Kober Kord M, Paul Steven M, Levine Jon D, Abrams Gary, Mastick Judy, Topp Kimberly, Conley Yvette P, Miaskowski Christine A
机构信息
Betty Smoot, PT, DPTSc, MAS, is Associate Professor, School of Medicine, University of California San Francisco. Kord M. Kober, PhD, is Assistant Professor; and Steven M. Paul, PhD, is Principal Statistician, School of Nursing, University of California San Francisco. Jon D. Levine, MD, is Professor; and Gary Abrams, MD, is Professor, School of Medicine, University of California San Francisco. Judy Mastick, RN, MN, is Project Director, School of Nursing, University of California San Francisco. Kimberly Topp, PT, PhD, is Professor, School of Medicine, University of California San Francisco. Yvette P. Conley, PhD, FAAN, is Professor, School of Nursing, University of Pittsburgh, Pennsylvania. Christine Miaskowski, PhD, RN, FAAN, is Professor, School of Nursing, University of California San Francisco.
出版信息
Nurs Res. 2017 Mar/Apr;66(2):85-94. doi: 10.1097/NNR.0000000000000203.
BACKGROUND
Potassium (K) channels play an important role in lymph pump activity, lymph formation, lymph transport, and the functions of lymph nodes. No studies have examined the relationship between K channel candidate genes and the development of secondary lymphedema (LE).
OBJECTIVE
The study purpose was to evaluate for differences in genotypic characteristics in women who did (n = 155) or did not (n = 387) develop upper extremity LE following breast cancer treatment based on an analysis of single-nucleotide polymorphisms (SNPs) and haplotypes in 10 K channel genes.
METHODS
Upper extremity LE was diagnosed using bioimpedance resistance ratios. Logistic regression analyses were used to identify those SNPs and haplotypes that were associated with LE while controlling for relevant demographic, clinical, and genomic characteristics.
RESULTS
Patients with LE had a higher body mass index, had a higher number of lymph nodes removed, had more advanced disease, received adjuvant chemotherapy, received radiation therapy, and were less likely to have undergone a sentinel lymph node biopsy. One SNP in a voltage-gated K channel gene (KCNA1 rs4766311), four in two inward-rectifying K channel genes (KCNJ3 rs1037091 and KCNJ6 rs2211845, rs991985, rs2836019), and one in a two-pore K channel gene (KCNK3 rs1662988) were associated with LE.
DISCUSSION
These preliminary findings suggest that K channel genes play a role in the development of secondary LE.
背景
钾（K）通道在淋巴泵活动、淋巴形成、淋巴运输及淋巴结功能中发挥重要作用。尚无研究探讨K通道候选基因与继发性淋巴水肿（LE）发生发展之间的关系。
目的
本研究旨在通过分析10个K通道基因的单核苷酸多态性（SNP）和单倍型，评估乳腺癌治疗后发生（n = 155）或未发生（n = 387）上肢LE的女性在基因型特征上的差异。
方法
采用生物电阻抗比值诊断上肢LE。运用逻辑回归分析确定与LE相关的SNP和单倍型，同时控制相关人口统计学、临床和基因组特征。
结果
LE患者的体重指数较高，切除的淋巴结数量较多，疾病分期较晚，接受辅助化疗和放疗，且接受前哨淋巴结活检的可能性较小。电压门控K通道基因（KCNA1 rs4766311）中的一个SNP、两个内向整流K通道基因（KCNJ3 rs1037091和KCNJ6 rs2211845、rs991985、rs2836019）中的四个SNP以及双孔K通道基因（KCNK3 rs1662988）中的一个SNP与LE相关。
讨论
这些初步研究结果表明，K通道基因在继发性LE的发生发展中起作用。
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