Center for Biomolecular Science and Engineering, School of Engineering, University of California Santa Cruz (UCSC), 1156 High Street, Santa Cruz, CA 95064, USA, Computational Biology Graduate Group, University of California Berkeley, Berkeley, CA 94720, USA, Department of Genetics, Stanford University School of Medicine, 3165 Porter Drive, Stanford, CA 94305, USA and Howard Hughes Medical Institute, Center for Biomolecular Science and Engineering, UCSC, 1156 High Street, Santa Cruz, CA 95064, USA.
Nucleic Acids Res. 2014 Jan;42(Database issue):D764-70. doi: 10.1093/nar/gkt1168. Epub 2013 Nov 21.
The University of California Santa Cruz (UCSC) Genome Browser (http://genome.ucsc.edu) offers online public access to a growing database of genomic sequence and annotations for a large collection of organisms, primarily vertebrates, with an emphasis on the human and mouse genomes. The Browser's web-based tools provide an integrated environment for visualizing, comparing, analysing and sharing both publicly available and user-generated genomic data sets. As of September 2013, the database contained genomic sequence and a basic set of annotation 'tracks' for ∼90 organisms. Significant new annotations include a 60-species multiple alignment conservation track on the mouse, updated UCSC Genes tracks for human and mouse, and several new sets of variation and ENCODE data. New software tools include a Variant Annotation Integrator that returns predicted functional effects of a set of variants uploaded as a custom track, an extension to UCSC Genes that displays haplotype alleles for protein-coding genes and an expansion of data hubs that includes the capability to display remotely hosted user-provided assembly sequence in addition to annotation data. To improve European access, we have added a Genome Browser mirror (http://genome-euro.ucsc.edu) hosted at Bielefeld University in Germany.
加州大学圣克鲁兹分校（UCSC）基因组浏览器（http://genome.ucsc.edu）提供了一个在线公共访问的不断增长的基因组序列和注释数据库，用于大量生物，主要是脊椎动物，重点是人类和小鼠基因组。浏览器的基于网络的工具提供了一个集成的环境，用于可视化、比较、分析和共享公共可用和用户生成的基因组数据集。截至 2013 年 9 月，该数据库包含基因组序列和一组基本的注释 '轨道'，约有 90 个生物。显著的新注释包括一个 60 种的鼠标多重比对保护轨道，更新的人类和小鼠 UCSC Genes 轨道，以及一些新的变异和 ENCODE 数据集。新的软件工具包括一个变异注释整合器，它返回一组作为自定义轨道上传的变体的预测功能影响，一个扩展的 UCSC Genes，用于显示蛋白质编码基因的单倍型等位基因，以及一个扩展的数据中心，包括显示远程托管的用户提供的组装序列的能力，除了注释数据。为了改善欧洲的访问，我们在德国比勒费尔德大学增加了一个基因组浏览器镜像（http://genome-euro.ucsc.edu）。
