某些光疗药物对环磷酸腺苷磷酸二酯酶的抑制作用。
Inhibition of cAMP phosphodiesterase by some phototherapeutic agents.
作者信息
Bovalini L, Lusini P, Simoni S, Vedaldi D, Andreassi L, Dall'Acqua F, Martelli P
机构信息
Institute of Biological Chemistry, University of Siena, Italy.
出版信息
Z Naturforsch C J Biosci. 1987 Jul-Aug;42(7-8):1009-10. doi: 10.1515/znc-1987-7-849.
The behaviour of cyclic-3',5'-AMP phosphodiesterase has been studied in the presence of psoralen, 8-methoxy-psoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP) (usually used in PUVA therapy), 4,6,4'-trimethylangelicin (TMA) and khellin recently proposed for the same therapeutical use. TMP and TMA exhibit a significant inhibitory effect on cyclic AMP phosphodiesterase; a light inhibition is produced by khellin at rather high concentration.
在补骨脂素、8-甲氧基补骨脂素（8-MOP）、4,5',8-三甲基补骨脂素（TMP）（通常用于光化学疗法）、4,6,4'-三甲基白芷素（TMA）和最近也被提议用于相同治疗用途的凯林存在的情况下，对环磷腺苷磷酸二酯酶的行为进行了研究。TMP和TMA对环磷腺苷磷酸二酯酶表现出显著的抑制作用；凯林在相当高的浓度下产生轻微的抑制作用。
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