补骨脂素对大鼠肝脏环磷酸腺苷磷酸二酯酶的抑制作用。
Inhibitory effects of psoralens on rat liver cyclic AMP phosphodiesterase.
作者信息
Bovalini L, Lusini P, Simoni S, Vedaldi D, Andreassi L, Dall'Acqua F, Martelli P
机构信息
Institute of Biological Chemistry, University of Siena, Italy.
出版信息
Biochem Int. 1988 Jun;16(6):991-8.
PMID:2845992
Abstract
TMP (4,5',8-trimethylpsoralen) usually employed in PUVA therapy and TMA (4,6,4'-trimethylangelicin), phototherapeutic agent under clinical and biological investigation, show an inhibitory effect of competitive type on the low Km cyclic AMP phosphodiesterase present in rat liver. The two drugs exhibit Ki values of 135 and 320 microM, respectively.
摘要
通常用于光化学疗法的甲氧沙林（4,5',8-三甲基补骨脂素）和正在进行临床及生物学研究的光疗药物三甲沙林（4,6,4'-三甲基白芷素），对大鼠肝脏中存在的低Km环磷酸腺苷磷酸二酯酶表现出竞争性抑制作用。这两种药物的抑制常数（Ki）值分别为135和320微摩尔。
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