Esteban J M, Zaloudek C, Silverberg S G
Department of Pathology, George Washington University Medical Center, Washington, D.C. 20037.
Am J Clin Pathol. 1987 Dec;88(6):681-8. doi: 10.1093/ajcp/88.6.681.
A retrospective double-blind examination of the cytologic smears and frozen section tissue slides from 140 lesions of the breast was performed in order to assess the diagnostic accuracy of each method. The cases with diagnostic errors were reevaluated to define the pitfalls encountered in the intraoperative diagnosis of breast lesions by both methods. Results with the cytologic technics are more variable than with frozen sections, but when read by experienced observers the smears are as accurate as frozen sections and have the additional advantages of rapidity, sparing of tissue for other studies, better correlation with fine-needle aspiration cytologic results, and more complete sampling of large or multiple specimens. The authors recommend that intraoperative cytologic examination be employed routinely in breast diagnosis, initially always in conjunction with frozen section examination but eventually in many cases as an alternative technic.
为了评估每种方法的诊断准确性，对140例乳腺病变的细胞学涂片和冰冻切片组织玻片进行了回顾性双盲检查。对存在诊断错误的病例进行了重新评估，以确定两种方法在乳腺病变术中诊断中遇到的陷阱。细胞学技术的结果比冰冻切片更具变异性，但由经验丰富的观察者阅读时，涂片与冰冻切片一样准确，并且具有快速、节省组织用于其他研究、与细针穿刺细胞学结果相关性更好以及对大标本或多个标本采样更完整等额外优点。作者建议术中细胞学检查应常规用于乳腺诊断，最初总是与冰冻切片检查联合使用，但最终在许多情况下可作为替代技术。
