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2型糖尿病患者颈动脉内膜中层增厚的变化：西他列汀内膜中层厚度评估预防研究的亚组分析

Changes in carotid intima-media thickening in patients with type 2 diabetes mellitus: Subanalysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation.

作者信息

Mita Tomoya, Katakami Naoto, Shiraiwa Toshihiko, Yoshii Hidenori, Gosho Masahiko, Shimomura Iichiro, Watada Hirotaka

机构信息

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

出版信息

J Diabetes Investig. 2017 Mar;8(2):254-255. doi: 10.1111/jdi.12559.

DOI:10.1111/jdi.12559
PMID:28256102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5334297/
Abstract

Figure 1 shows differences in treatment-induced delta change in carotid IMT relative to baseline, according to various pre-defined risk factors for atherosclerosis. These data suggest that treatment with DPP-4 inhibitors seem to prevent the progression of carotid atherosclerosis regardless of disease burden.

摘要

图1显示了根据动脉粥样硬化的各种预定义风险因素，治疗引起的颈动脉内膜中层厚度相对于基线的变化差异。这些数据表明，无论疾病负担如何，使用二肽基肽酶-4抑制剂进行治疗似乎都能预防颈动脉粥样硬化的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e5/5334297/f1de2f9093be/JDI-8-254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e5/5334297/f1de2f9093be/JDI-8-254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53e5/5334297/f1de2f9093be/JDI-8-254-g001.jpg

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Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial.西他列汀减缓胰岛素治疗的2型糖尿病患者颈动脉内膜中层增厚的进展：西他列汀内膜中层厚度评估预防研究（SPIKE）：一项随机对照试验。
Diabetes Care. 2016 Mar;39(3):455-64. doi: 10.2337/dc15-2145. Epub 2016 Jan 28.
2
Atorvastatin Treatment for Carotid Intima-Media Thickness in Chinese Patients With Type 2 Diabetes: A Meta-Analysis.阿托伐他汀治疗中国 2 型糖尿病患者颈动脉内膜中层厚度：一项荟萃分析。
Medicine (Baltimore). 2015 Nov;94(44):e1920. doi: 10.1097/MD.0000000000001920.
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The journey to understanding incretin systems: Theory, practice and more theory.
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