A model to account for the effects of oncogenes, TPA, and retinoic acid on the regulation of genes involved in metastasis.

We have postulated that signals from the microenvironment can induce shifts in tumor cell phenotypes and that microenvironmental factors are therefore important for cancer metastasis. In this article we expand on this hypothesis and propose a model to explain (a) how extracellular signals can lead to changes in tumor phenotypes, and (b) how cytoplasmic oncogenes, which influence signal transducing pathways as well as nuclear oncogenes regulating gene expression via DNA binding transacting factors, might affect metastatic competence.