Gutkind J S, Kurihara M, Castrén E, Saavedra J M
Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Biochem Biophys Res Commun. 1987 Nov 30;149(1):65-72. doi: 10.1016/0006-291x(87)91605-6.
High concentration of atrial natriuretic peptide (99-126) (ANP) receptors were localized by quantitative autoradiography in superior cervical and stellate ganglia from young and adult Wistar Kyoto (WKY) rats. ANP increased cyclic GMP formation in stellate ganglia from adult rats. Both young and adult spontaneously hypertensive rats (SHR) had a much lower number of ANP receptors in the sympathetic ganglia. In spite of low receptor concentration, the cyclic GMP response to ANP in SHR was unchanged. These results suggest the existence of physiologically active ANP receptors in the rat sympathetic ganglia. These receptors may also be involved in the pathophysiology of spontaneous hypertension.
通过定量放射自显影法，在幼年和成年Wistar Kyoto（WKY）大鼠的颈上神经节和星状神经节中定位了高浓度的心房利钠肽（99 - 126）（ANP）受体。ANP可增加成年大鼠星状神经节中环鸟苷酸（cGMP）的生成。幼年和成年自发性高血压大鼠（SHR）交感神经节中的ANP受体数量均显著减少。尽管受体浓度较低，但SHR对ANP的cGMP反应未发生改变。这些结果表明大鼠交感神经节中存在具有生理活性的ANP受体。这些受体可能也参与了自发性高血压的病理生理过程。
