Kurihara M, Castrén E, Gutkind J S, Saavedra J M
Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Biochem Biophys Res Commun. 1987 Dec 31;149(3):1132-40. doi: 10.1016/0006-291x(87)90526-2.
Spontaneously hypertensive rats (SHR) have a much lower number of atrial natriuretic peptide (ANP) receptors in thymus and spleen from young and adult animals than age-matched normotensive controls. In spite of this low receptor concentration, the ANP-stimulated cyclic GMP response in isolated thymocytes and spleen cells from SHR was similar to that of normotensive control rats. Alterations in ANP receptor concentration in thymus and spleen of SHR may be related to the immune abnormalities described in these animals, and to the pathophysiology of genetic hypertension.
自发性高血压大鼠（SHR）在幼年和成年动物的胸腺和脾脏中，心房利钠肽（ANP）受体的数量比年龄匹配的正常血压对照动物少得多。尽管受体浓度较低，但SHR分离的胸腺细胞和脾细胞中ANP刺激的环磷酸鸟苷反应与正常血压对照大鼠相似。SHR胸腺和脾脏中ANP受体浓度的改变可能与这些动物中描述的免疫异常以及遗传性高血压的病理生理学有关。
