来自对叶刺核藤的新型细胞毒性裂环型三萜和半日花烷型二萜

New Cytotoxic Seco-Type Triterpene and Labdane-Type Diterpenes from Nuxia oppositifolia.

作者信息

Al-Massarani Shaza M, El-Gamal Ali A, Parvez Mohammad K, Al-Dosari Mohammed S, Al-Said Mansour S, Abdel-Kader Maged S, Basudan Omer A

机构信息

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, El-Mansoura 35516, Egypt.

出版信息

Molecules. 2017 Mar 2;22(3):389. doi: 10.3390/molecules22030389.

DOI:10.3390/molecules22030389

PMID:28257105

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6155346/

Abstract

Chromatographic purification of the -hexane and dichloromethane extracts of aerial parts, growing in Saudi Arabia, resulted in the isolation and characterization of three new labdane-type diterpene acids, 2β-acetoxy-labda-7-en-15-oic acid (), 2β-acetoxy-7-oxolabda-8-en-15-oic acid (), 2β-acetoxy-6-oxolabda-7-en-15-oic acid (), and one new seco-triterpene, 3,4-seco olean-12-en-3,30 dioic acid (), together with 10 known lupane, oleanane and ursane-type triterpenes, as well as the common phytosterols, β-sitosterol and stigmasterol (-). Their structures have been assigned on the basis of different spectroscopic techniques including 1D and 2D NMR. Moreover, 13 of the isolated compounds were tested on the human cancer cell lines HeLa (cervical), A549 (lung) and MDA (breast), and most of the compounds showed potent cytotoxic activities in vitro.

摘要

对生长在沙特阿拉伯的地上部分的己烷和二氯甲烷提取物进行色谱纯化，结果分离并鉴定出三种新的半日花烷型二萜酸，即2β - 乙酰氧基 - 半日花 - 7 - 烯 - 15 - 酸（）、2β - 乙酰氧基 - 7 - 氧代半日花 - 8 - 烯 - 15 - 酸（）、2β - 乙酰氧基 - 6 - 氧代半日花 - 7 - 烯 - 15 - 酸（），以及一种新的裂环三萜，3,4 - 裂环齐墩果 - 12 - 烯 - 3,30 - 二酸（），同时还有10种已知的羽扇豆烷型、齐墩果烷型和乌苏烷型三萜，以及常见的植物甾醇，β - 谷甾醇和豆甾醇（ - ）。它们的结构已通过包括一维和二维核磁共振在内的不同光谱技术确定。此外，对分离出的13种化合物在人癌细胞系HeLa（宫颈癌）、A549（肺癌）和MDA（乳腺癌）上进行了测试，大多数化合物在体外显示出强大的细胞毒活性。