桑寄生中齐墩果酸的细胞毒活性及新三萜3,4-裂环齐墩果-18-烯-3,28-二酸的鉴定

Cytotoxic activity of moronic acid and identification of the new triterpene 3,4-seco-olean-18-ene-3,28-dioic acid from Phoradendron reichenbachianum.

作者信息

Rios M Y, Salina D, Villarreal M L

机构信息

Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico.

出版信息

Planta Med. 2001 Jul;67(5):443-6. doi: 10.1055/s-2001-15823.

DOI:10.1055/s-2001-15823

PMID:11488459

Abstract

The cytotoxic compound moronic acid (1) and the new tetracyclic triterpene 3,4-seco-olean-18-ene-3,28-dioic acid (2), were isolated from the aerial parts of the medicinal plant Phoradendron reichenbachianum (mistletoe, Loranthaceae) through a bioassay-guided fractionation. In addition, squalene, glycerol trilinoleate, morolic acid, betulonaldehyde, betulinaldehyde, alpha-germanicol, lupeol, beta-sitosterol and beta-sitosteril glucopyranoside, were identified in this plant species. The structures were elucidated on the basis of chemical and spectroscopic evidence.

摘要

通过生物活性导向分离法，从药用植物赖氏槲寄生（桑寄生科槲寄生）的地上部分分离出了细胞毒性化合物莫诺酸（1）和新的四环三萜3,4-裂环齐墩果-18-烯-3,28-二酸（2）。此外，还在该植物中鉴定出了角鲨烯、甘油三亚油酸酯、莫洛酸、桦木醛、桦木醛、α-吉马萜醇、羽扇豆醇、β-谷甾醇和β-谷甾醇葡萄糖苷。这些结构是根据化学和光谱证据阐明的。