Domingues-Faria Carla, Boirie Yves, Walrand Stéphane
aUnité de Nutrition Humaine, UMR 1019 INRA UCA, Equipe ASMS, CRNH Auvergne bUniversité Clermont Auvergne cService de Nutrition Clinique, CHU Clermont-Ferrand, France.
Curr Opin Clin Nutr Metab Care. 2017 May;20(3):169-174. doi: 10.1097/MCO.0000000000000358.
We review recent findings on the involvement of vitamin D in skeletal muscle trophicity.
Vitamin D deficiencies are associated with reduced muscle mass and strength, and its supplementation seems effective to improve these parameters in vitamin D-deficient study participants. Latest investigations have also evidenced that vitamin D is essential in muscle development and repair. In particular, it modulates skeletal muscle cell proliferation and differentiation. However, discrepancies still exist about an enhancement or a decrease of muscle proliferation and differentiation by the vitamin D. Recently, it has been demonstrated that vitamin D influences skeletal muscle cell metabolism as it seems to regulate protein synthesis and mitochondrial function. Finally, apart from its genomic and nongenomic effects, recent investigations have demonstrated a genetic contribution of vitamin D to muscle functioning.
Recent studies support the importance of vitamin D in muscle health, and the impact of its deficiency in regard to muscle mass and function. These 'trophic' properties are of particular importance for some specific populations such as elderly persons and athletes, and in situations of loss of muscle mass or function, particularly in the context of chronic diseases.
我们综述了维生素D与骨骼肌营养状况相关的最新研究发现。
维生素D缺乏与肌肉量和力量降低有关，在维生素D缺乏的研究参与者中补充维生素D似乎对改善这些参数有效。最新研究还证明维生素D在肌肉发育和修复中至关重要。特别是，它调节骨骼肌细胞的增殖和分化。然而，关于维生素D对肌肉增殖和分化是增强还是降低仍存在差异。最近，已证明维生素D影响骨骼肌细胞代谢，因为它似乎调节蛋白质合成和线粒体功能。最后，除了其基因组和非基因组效应外，最近的研究表明维生素D对肌肉功能有遗传贡献。
最近的研究支持了维生素D在肌肉健康中的重要性，以及其缺乏对肌肉量和功能的影响。这些“营养”特性对一些特定人群，如老年人和运动员，以及在肌肉量或功能丧失的情况下，特别是在慢性疾病背景下，尤为重要。
