• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一项关于野生鼠尾草代谢物在健康成年人中预防打鼾、改善睡眠及激活阿尔法脑波频率的安全性和有效性的随机、双盲、安慰剂对照评估。

A Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Wild Sage Metabolites in Preventing Snoring, Improving Sleep, and Activating Alpha Wave Brain Frequencies in Healthy Adults.

作者信息

Ikeda Yuki, Nasu Mizuho

机构信息

Microbiology, Innovation Labo Research Center, Tokyo, JPN.

Pharmacology, Innovation Labo Research Center, Tokyo, JPN.

出版信息

Cureus. 2022 Feb 28;14(2):e22714. doi: 10.7759/cureus.22714. eCollection 2022 Feb.

DOI:10.7759/cureus.22714
PMID:35386141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8967657/
Abstract

Upper airway problems and stress can cause sleep disorders. The present study was designed to evaluate the efficacy and safety of wild sage metabolites (WSM) for snoring treatment and alpha wave activation in healthy men and women. A total of 42 subjects compliant with inclusion criteria were randomly assigned to one of the two groups, viz. Group 1-WSM and Group 2-Placebo, using a simple randomization process. Consumption of WSM by healthy men and women resulted in the decrease of Pittsburgh Sleep Quality Index (PSQI) global score by 29%, improved assessment by their sleep mates, and increased alpha brain wave by 55%. In conclusion, medication with WSM resulted in significant reduced snoring, stress, and improved sleep quality after 30 days, with a good tolerance among subjects. No side effects or adverse events were reported during the study. Hence, WSM at 450 mg/day could be recommended as an effective agent for snoring treatment, improving the quality of sleep, and stress reduction.

摘要

上呼吸道问题和压力会导致睡眠障碍。本研究旨在评估野生鼠尾草代谢产物（WSM）对健康男性和女性打鼾治疗及α波激活的有效性和安全性。采用简单随机化方法，将42名符合纳入标准的受试者随机分为两组，即第1组-WSM组和第2组-安慰剂组。健康男性和女性服用WSM后，匹兹堡睡眠质量指数（PSQI）全球评分降低了29%，睡眠伙伴的评估得到改善，α脑波增加了55%。总之，服用WSM 30天后，打鼾、压力显著减轻，睡眠质量得到改善，受试者耐受性良好。研究期间未报告副作用或不良事件。因此，建议每天服用450毫克WSM作为治疗打鼾、改善睡眠质量和减轻压力的有效药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabd/8967657/644844ab0ef1/cureus-0014-00000022714-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabd/8967657/838f1ef58781/cureus-0014-00000022714-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabd/8967657/35049654057e/cureus-0014-00000022714-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabd/8967657/3b08a167a5e4/cureus-0014-00000022714-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabd/8967657/644844ab0ef1/cureus-0014-00000022714-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabd/8967657/838f1ef58781/cureus-0014-00000022714-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabd/8967657/35049654057e/cureus-0014-00000022714-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabd/8967657/3b08a167a5e4/cureus-0014-00000022714-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabd/8967657/644844ab0ef1/cureus-0014-00000022714-i04.jpg

相似文献

1
A Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Wild Sage Metabolites in Preventing Snoring, Improving Sleep, and Activating Alpha Wave Brain Frequencies in Healthy Adults.一项关于野生鼠尾草代谢物在健康成年人中预防打鼾、改善睡眠及激活阿尔法脑波频率的安全性和有效性的随机、双盲、安慰剂对照评估。
Cureus. 2022 Feb 28;14(2):e22714. doi: 10.7759/cureus.22714. eCollection 2022 Feb.
2
Effect of a Multi-Layer, Extended-Release Methylphenidate Formulation (PRC-063) on Sleep in Adults with ADHD: A Randomized, Double-Blind, Forced-Dose, Placebo-Controlled Trial Followed by a 6-month Open-Label Extension.多层面、缓释哌醋甲酯制剂（PRC-063）对 ADHD 成人睡眠的影响：一项随机、双盲、强制剂量、安慰剂对照试验，随后进行 6 个月的开放标签扩展。
CNS Drugs. 2021 Jun;35(6):667-679. doi: 10.1007/s40263-021-00814-z. Epub 2021 May 31.
3
Safety and Efficacy of N-SORB, a Proprietary KD120 MEC Metabolically Activated Enzyme Formulation: A Randomized, Double-Blind, Placebo-Controlled Study.N-SORB，一种专有的 KD120 MEC 代谢激活酶配方的安全性和疗效：一项随机、双盲、安慰剂对照研究。
J Am Coll Nutr. 2019 Sep-Oct;38(7):577-585. doi: 10.1080/07315724.2019.1586591. Epub 2019 Apr 11.
4
Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study.临床评价：南非醉茄根提取物对健康志愿者和失眠症患者睡眠的药理影响：一项双盲、随机、平行分组、安慰剂对照研究。
J Ethnopharmacol. 2021 Jan 10;264:113276. doi: 10.1016/j.jep.2020.113276. Epub 2020 Aug 17.
5
Effect of a Multilayer, Extended-Release Methylphenidate Formulation (PRC-063) on Sleep in Adolescents with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Fixed-Dose, Placebo-Controlled Trial Followed by a 6-Month Open-Label Follow-Up.一种多层、缓释哌甲酯制剂（PRC-063）对注意缺陷多动障碍青少年睡眠的影响：一项随机、双盲、固定剂量、安慰剂对照试验，随后进行 6 个月的开放标签随访。
J Child Adolesc Psychopharmacol. 2021 Nov;31(9):623-630. doi: 10.1089/cap.2021.0087. Epub 2021 Oct 28.
6
Impact of stimulant pharmacotherapy on sleep quality: post hoc analyses of 2 large, double-blind, randomized, placebo-controlled trials.兴奋剂药物治疗对睡眠质量的影响：两项大型、双盲、随机、安慰剂对照试验的事后分析。
J Clin Psychiatry. 2011 Jul;72(7):903-8. doi: 10.4088/JCP.11m06838.
7
Effectiveness of Yi-Zhi-An-Shen granules on cognition and sleep quality in older adults with amnestic mild cognitive impairment: protocol for a randomized, double-blind, placebo-controlled trial.益肾安神颗粒治疗遗忘型轻度认知障碍老年人认知和睡眠质量的有效性：一项随机、双盲、安慰剂对照试验方案。
Trials. 2019 Aug 20;20(1):518. doi: 10.1186/s13063-019-3607-x.
8
The Effect of A Whey-Protein and Galacto-Oligosaccharides Based Product on Parameters of Sleep Quality, Stress, and Gut Microbiota in Apparently Healthy Adults with Moderate Sleep Disturbances: A Randomized Controlled Cross-Over Study.一种乳清蛋白和半乳糖寡糖为基础的产品对有中度睡眠障碍的健康成年人的睡眠质量、压力和肠道微生物群参数的影响：一项随机对照交叉研究。
Nutrients. 2021 Jun 27;13(7):2204. doi: 10.3390/nu13072204.
9
Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder.儿童自闭症谱系障碍失眠症使用长效褪黑素缓释剂的长期疗效与安全性
J Child Adolesc Psychopharmacol. 2018 Dec;28(10):699-710. doi: 10.1089/cap.2018.0020. Epub 2018 Oct 11.
10
Effects of protriptyline on snoring characteristics.普罗替林对打鼾特征的影响。
Chest. 1993 Jul;104(1):14-8. doi: 10.1378/chest.104.1.14.

本文引用的文献

1
The interplay between sleep and gut microbiota.睡眠与肠道微生物群的相互作用。
Brain Res Bull. 2022 Mar;180:131-146. doi: 10.1016/j.brainresbull.2021.12.016. Epub 2022 Jan 13.
2
Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.口服γ-氨基丁酸（GABA）对人类压力和睡眠的影响：一项系统综述。
Front Neurosci. 2020 Sep 17;14:923. doi: 10.3389/fnins.2020.00923. eCollection 2020.
3
Stress, depression, diet, and the gut microbiota: human-bacteria interactions at the core of psychoneuroimmunology and nutrition.
压力、抑郁、饮食与肠道微生物群：心理神经免疫学和营养核心的人与细菌相互作用
Curr Opin Behav Sci. 2019 Aug;28:105-110. doi: 10.1016/j.cobeha.2019.01.011. Epub 2019 Mar 25.
4
Vitamin D and Sleep Regulation: Is there a Role for Vitamin D?维生素 D 与睡眠调节：维生素 D 是否发挥作用？
Curr Pharm Des. 2020;26(21):2492-2496. doi: 10.2174/1381612826666200310145935.
5
Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats.肠道微生物群的操纵使成年大鼠对高碳酸血症的通气反应迟钝。
EBioMedicine. 2019 Jun;44:618-638. doi: 10.1016/j.ebiom.2019.03.029. Epub 2019 Mar 18.
6
The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis.维生素 D 缺乏与睡眠障碍的关联：系统评价和荟萃分析。
Nutrients. 2018 Oct 1;10(10):1395. doi: 10.3390/nu10101395.
7
Neurotransmitter modulation by the gut microbiota.肠道微生物群对神经递质的调节作用。
Brain Res. 2018 Aug 15;1693(Pt B):128-133. doi: 10.1016/j.brainres.2018.03.015.
8
The interfaces between vitamin D, sleep and pain.维生素D、睡眠与疼痛之间的关联
J Endocrinol. 2017 Jul;234(1):R23-R36. doi: 10.1530/JOE-16-0514. Epub 2017 May 23.
9
Vitamin D and muscle trophicity.维生素D与肌肉营养状况
Curr Opin Clin Nutr Metab Care. 2017 May;20(3):169-174. doi: 10.1097/MCO.0000000000000358.
10
Vitamin D's role in cell proliferation and differentiation.维生素D在细胞增殖和分化中的作用。
Nutr Rev. 2008 Oct;66(10 Suppl 2):S116-24. doi: 10.1111/j.1753-4887.2008.00094.x.